Is the oxidation of high-density lipoprotein lipids different than the oxidation of low-density lipoprotein lipids?

Biochemistry
M J ThomasL L Rudel

Abstract

This article gives detailed insight into the kinetics of high-density lipoprotein (HDL) oxidation catalyzed by azobis(2-amidinopropane).dihydrochloride (ABAP) or by copper. ABAP initialized oxidation of human HDL 3-4 times faster than non-human primate HDL with a similar composition. The oxidizability of non-human primate HDL was 1000 times lower than the oxidizability calculated from rate constants derived from liposome oxidation, suggesting that there is a slow step in HDL oxidation not present in liposomes. Saturable binding of copper to HDL was a significant feature of copper-catalyzed oxidation. Binding constants (K(m)) for non-human primate HDL were 2-3-fold lower than those for human HDL. Copper-catalyzed oxidation of non-human primate HDL was slower than that of human HDL, but human HDL(2) and HDL(3) oxidized at about the same rate. Overall, the kinetics describing the oxidation of HDL were mechanistically similar to those reported for LDL, suggesting that HDL lipids were as easily oxidized as LDL lipids and that HDL will be easily oxidized in vivo when exposed to agents that oxidize LDL.

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Citations

Feb 1, 2009·Clinical Lipidology·Mary G Sorci-ThomasMichael J Thomas
Nov 2, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Bhagu R Bhavnani, Frank Z Stanczyk
Nov 5, 2011·Biochimica Et Biophysica Acta·Kerry-Anne Rye, Philip J Barter
Mar 21, 2006·Journal of the American Academy of Dermatology·Lotus MallbrisMona Ståhle
Jan 5, 2006·Free Radical Research·Natasa StojanovićJanko N Herak
Oct 29, 2002·Journal of Lipid Research·Dawn C SchwenkeMichael J Thomas
Jul 27, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ayla YalamanogluPaul W Buehler
Mar 22, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Hiroshi NotoKazuhisa Tsukamoto
Jan 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·Jahangir Iqbal, M Mahmood Hussain
Oct 2, 2003·The Journal of Nutrition·Robert J HillstromSean M Lynch

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