Is the pan-genome also a pan-selectome?

F1000Research
Francisco Rodriguez-Valera, David W Ussery

Abstract

The comparative genomics of prokaryotes has shown the presence of conserved regions containing highly similar genes (the 'core genome') and other regions that vary in gene content (the 'flexible' regions). A significant part of the latter is involved in surface structures that are phage recognition targets. Another sizeable part provides for differences in niche exploitation. Metagenomic data indicates that natural populations of prokaryotes are composed of assemblages of clonal lineages or "meta-clones" that share a core of genes but contain a high diversity by varying the flexible component. This meta-clonal diversity is maintained by a collection of phages that equalize the populations by preventing any individual clonal lineage from hoarding common resources. Thus, this polyclonal assemblage and the phages preying upon them constitute natural selection units.

References

Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M T CleggA L Kahler
Jan 1, 1967·Annual Review of Microbiology·R J Roantree
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·E Mayr
Aug 28, 2001·Biochimie·C Schäffer, P Messner
Mar 8, 2005·Endeavour·Mark E Borrello
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kevin de Queiroz
Sep 15, 2005·Journal of Bacteriology·Konstantinos T Konstantinidis, James M Tiedje
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hervé TettelinClaire M Fraser
Mar 25, 2006·Science·Maureen L ColemanSallie W Chisholm
Nov 9, 2007·Biology Direct·Larry J WilhelmStephen J Giovannoni
Nov 29, 2007·The ISME Journal·Sara Cuadros-OrellanaFrancisco Rodriguez-Valera
Dec 28, 2007·PLoS Genetics·Gregory C KettlerSallie W Chisholm
Dec 11, 2008·Journal of Theoretical Biology·Duncan N L Menge, Joshua S Weitz
Feb 17, 2009·Applied and Environmental Microbiology·Elisabeth BonClaire Le Marrec
Aug 21, 2009·BMC Genomics·Lars SnipenDavid W Ussery
Oct 14, 2009·BMC Biology·Oliver MirusEnrico Schleiff
Oct 17, 2009·Nature Reviews. Microbiology·Francisco Rodriguez-ValeraAlex Mira
Dec 3, 2009·BMC Genomics·Lejla PasićFrancisco Rodriguez-Valera
Dec 17, 2009·Environmental Microbiology·Roland J SiezenJohan E T van Hylckama Vlieg
Feb 12, 2010·The ISME Journal·Beltran Rodriguez-BritoForest Rohwer
Feb 26, 2010·Nature·Steve PatersonMichael A Brockhurst
Jul 14, 2010·Microbial Ecology·Oksana LukjancenkoDavid W Ussery
Dec 24, 2010·PloS One·Delphine PasseriniPascal Le Bourgeois
Feb 15, 2011·Applied and Environmental Microbiology·Antonina AydanianO Colin Stine
Feb 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth E HansenJeffrey I Gordon
Jul 7, 2011·Bioscience·Mitch D DayJames A Foster
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Evan S SnitkinJulie A Segre
Oct 26, 2011·Microbial Cell Factories·Bas TeusinkDouwe Molenaar
Oct 18, 2011·International Journal of Medical Microbiology : IJMM·Alessandro Muzzi, Claudio Donati
Nov 1, 2011·PloS One·Pedro Belda-FerreAlex Mira
Dec 14, 2011·Environmental Microbiology·Alejandro Caro-Quintero, Konstantinos T Konstantinidis
Dec 16, 2011·The ISME Journal·Mads AlbertsenKåre Lehmann Nielsen
Mar 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marcia F MarstonJennifer B H Martiny
Mar 31, 2012·Annual Review of Marine Science·Mya Breitbart
Jun 9, 2012·Current Biology : CB·W Ford Doolittle

❮ Previous
Next ❯

Citations

Dec 2, 2014·Pathogens·Jason S LehmannDerrick E Fouts
Aug 14, 2015·BMC Genomics·Ana-Belen Martin-CuadradoFrancisco Rodriguez-Valera
Dec 2, 2014·Nature Reviews. Microbiology·Steven J BillerSallie W Chisholm
Dec 19, 2013·PLoS Genetics·Carolina Megumi MizunoRohit Ghai
Apr 28, 2016·BMC Genomics·Peter R Sternes, Anthony R Borneman
May 18, 2016·Genome Biology and Evolution·Mario López-Pérez, Francisco Rodriguez-Valera
Mar 13, 2014·Bacteriophage·Francisco Rodriguez-ValeraRohit Ghai
Jun 5, 2013·Genome Biology and Evolution·Mario López-PérezFrancisco Rodriguez-Valera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.