Is the place cell a "supple" engram?

Hippocampus
Aryeh Routtenberg

Abstract

This short note, which honors Nobelists O'Keefe and the Mosers, asks how the patterning of inputs to a single place cell regulates its firing. Because the combination of inputs to a single CA1 place cell is very large, the generally accepted view is rejected that inputs to a place cell are relatively restricted, near identical repetition upon re-presentation of the environment. The alternative proposed here is that when any 100 excitatory inputs are fired activating a subset combination, which is a large number, selected from the 30,000 synapses, this leads to CA1 cell firing. The selection of the combination of inputs is a very large number it nonetheless leads to the conclusion that even though the same cell dutifully fires when the animal is in an identical location, the inputs that fire the place cell are nonetheless obligatorily non-identical. This CA1 input combinatorial proposal may help us understand the physiological underpinnings of the memory mechanism arising from supple synapses (Routtenberg (2013), Hippocampus 23:202-206).

References

Apr 1, 1976·Experimental Neurology·J O'Keefe
Nov 24, 2004·Nature Neuroscience·Astrid A PrinzEve Marder
Nov 10, 2006·Hippocampus·Trygve SolstadGaute T Einevoll
Jun 29, 2007·Hippocampus·Neil BurgessJohn O'Keefe
Nov 21, 2008·Hippocampus·Edvard I Moser, May-Britt Moser
Mar 27, 2012·Nature Neuroscience·Sébastien RoyerGyörgy Buzsáki
Dec 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Guifen ChenJohn O'Keefe
Jan 29, 2013·Hippocampus·Aryeh Routtenberg
Oct 2, 2014·Nature Reviews. Neuroscience·Howard Eichenbaum
Dec 4, 2014·Current Biology : CB·Tale L BjerknesMay-Britt Moser
Dec 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Charlotte B AlmeMay-Britt Moser
Jan 21, 2015·Nature·Fabricio H Do-MonteGregory J Quirk

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Citations

Nov 17, 2020·Frontiers in Molecular Neuroscience·Francesco Gobbo, Antonino Cattaneo

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