Is the presence of a non-cleaved embryo on day 3 associated with poorer quality of the remaining embryos in the cohort?

Journal of Assisted Reproduction and Genetics
Ronit MachtingerCatherine Racowsky

Abstract

Morphological evaluation is currently considered the single most important predictive measure for assessing embryo quality. The aim of this study was to investigate whether cycles with at least one non-cleaved embryo (i.e., a 1-cell embryo on day 3) have different outcomes compared with cycles in which all embryos had cleaved by day 3. All autologous IVF/ICSI cycles with a fresh day 3 transfer and without using a gestational carrier performed at our center between 1/1/2010 and 12/31/2011 were analyzed retrospectively. Those cycles with at least one non-cleaved embryo on day 3 were compared with all other autologous cycles that had 100% cleaved embryos performed during the study period. Eight hundred and forty two cycles were included. Of them, 144 cycles comprised the non-cleaved group, and 698 cycles comprised the cleaved group. Cycles in the non-cleaved group had more oocytes retrieved (15.4 ± 7.1 vs. 12.5 ± 7.1, p < 0.001), more zygotes obtained (10.0 ± 5.3 vs. 7.9 ± 5.2, p = <0.001), but the embryos exhibited lower cleavage rates and higher rates of fragmentation and asymmetry compared with controls (p < 0.001). However, spontaneous abortion rates, ectopic pregnancies rates as well as delivery rates were similar between the...Continue Reading

References

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Jul 25, 2012·Journal of Assisted Reproduction and Genetics·Meng-Ju LeeYuh-Ming Hwu
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Jan 29, 2013·Reproductive Biomedicine Online·Ronit Machtinger, Catherine Racowsky
Feb 12, 2013·Fertility and Sterility·Javier Herrero, Marcos Meseguer

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Citations

Nov 20, 2018·Scientific Reports·Rosie M MartinezRonit Machtinger
Aug 4, 2017·Human Reproduction Open·UNKNOWN ESHRE Special Interest Group of Embryology, UNKNOWN Alpha Scientists in Reproductive Medicine

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