Is the rat pancreas an appropriate model of the human pancreas?

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
R M Case

Abstract

During my lifetime in pancreatic research, rat and mouse have largely replaced dog and cat in experimental studies. However, as this review clearly demonstrates, the anatomy, physiology and molecular cell biology of the rat pancreas (and also probably the mouse pancreas) differ substantially from those in humans. Indeed, they differ more in rat/mouse than any other common laboratory species. These differences may be irrelevant if one is using the pancreas as a generic model in which to study, say, acinar cell exocytosis or signalling. But if one is interested in more specific aspects of human pancreatic function, especially ductal function, in health and disease, in my opinion the simple answer to the question posed by the title of this article is no: other species are more appropriate.

References

Jan 1, 1979·Acta Physiologica Scandinavica·J J HolstJ Fahrenkrug
Mar 11, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·M Lampel, H F Kern
May 1, 1978·Biological Reviews of the Cambridge Philosophical Society·R M Case
Mar 2, 1978·Histochemistry·F SundlerO Schaffalitzky de Muckadell
Aug 1, 1991·The Journal of Clinical Investigation·C R MarinoJ A Cohn
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·I CrawfordC F Higgins
Jan 1, 1973·Digestion·H T Debas, M I Grossman
Jul 1, 1971·The Journal of Physiology·S Lenninger, P Ohlin
Apr 1, 1969·The Journal of Physiology·R M CaseT Scratcherd
Mar 1, 1983·Acta Pathologica Japonica·T Kodama
Mar 1, 1981·Acta Physiologica Scandinavica·S L JensenO B Schaffalitzky de Muckadell
May 1, 1980·The Journal of Surgical Research·J L AustinH A Reber
May 1, 1995·Pflügers Archiv : European journal of physiology·J P WinpennyB E Argent
Nov 1, 1995·Gastroenterology·A G PatelH A Reber
Dec 1, 1993·Scandinavian Journal of Gastroenterology·C P DelaneyJ M Fitzpatrick
Jan 1, 1997·Acta Physiologica Scandinavica·J GromadaS Dissing
Aug 26, 1998·The Journal of Physiology·H IshiguroR M Case
Jul 15, 1999·Biochemical and Biophysical Research Communications·J BourassaJ Morisset
Aug 24, 1999·The Journal of Physiology·H IshiguroM C Steward
Jan 24, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shigeru B H KoTetsuo Hayakawa
Nov 22, 2002·American Journal of Physiology. Cell Physiology·Hiroaki SatohGeorge Seki
Jan 11, 2003·The Journal of Biological Chemistry·Frank Ch MoorenMarkus M Lerch
Mar 4, 2003·Gastroenterology·Michael Blackstone
Oct 25, 2003·Pancreas·Stephen J PandolAnna S Gukovskaya
Feb 24, 2004·The Journal of Physiology·M Paz Fernández-SalazarJosé I San Román
Jun 24, 2004·Pancreas·Krisztina Sz KordásAgnes Kittel
Jul 21, 2004·Digestive Diseases and Sciences·Xiaoying DengDavid C Whitcomb
Oct 2, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·A ChaudhuriF S Gorelick
Feb 16, 2005·Annual Review of Physiology·Martin C StewardR Maynard Case

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Citations

Feb 28, 2009·Journal of Physiology and Biochemistry·M GarcíaJ J Calvo
Jul 27, 2006·The Journal of Membrane Biology·B BurghardtM C Steward
Mar 15, 2011·Lancet·Joan M BraganzaMichael J McMahon
Sep 12, 2009·Pancreas·Irma DemeterBeáta Burghardt
Dec 15, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Akos SzucsGábor Varga
Apr 11, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Charles J MirandaAjith K Siriwardena
Apr 10, 2012·Chemico-biological Interactions·Michael D CostaCristina W Nogueira
Jun 30, 2009·Journal of Vascular and Interventional Radiology : JVIR·Aaron C EiflerReed A Omary
Apr 28, 2009·The Journal of Surgical Research·Teemu LämsäIsto Nordback
Oct 1, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Mark J Truty, Rory L Smoot
May 16, 2007·ANZ Journal of Surgery·John C PapakostasMiltiadis I Matsagas
May 21, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Stephen C HanleyLawrence Rosenberg
Jun 5, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah KlaussIhsan Ekin Demir
Apr 26, 2021·Advanced Drug Delivery Reviews·Marcel A HeinrichJai Prakash
May 4, 2021·Digestive Diseases and Sciences·Lu WangDong Wu
Jul 20, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·José Marcus Raso EulálioJosé Eduardo Ferreira Manso
Dec 2, 2020·Current Drug Metabolism·Sangita Maiti DuttaSmarajit Maiti

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