Is the risk of urinary tract tumorigenesis enhanced by a marginal chronic essential fatty acid deficiency (EFAD)?

Aldo R Eynard


A considerable amount of experimental, clinical and epidemiological data indicate that dietary fats play a role in urinary tract tumorigenesis. In rodents, chronic essential fatty acid (EFA) deficiency seems to induce both urolithiasis and transitional hyperplasias, followed by a tendency for tumorigenesis of the urinary passages. High intake of saturated fats or non-EFAs, conditions that may induce EFA deficiency (EFAD) increase the risk of bladder cancer in case-control studies. In other cell populations, EFAs are beneficial as preventive and therapeutic nutrients for the treatment of cancer. Thus, it is reasonable to assume that abnormal metabolism and/or nutritional deprivation of EFA, by inducing a chronic or a subclinical EFA deficiency, may enhance the risk of urothelial tumorigenesis.


Jul 1, 1979·International Journal of Radiation Oncology, Biology, Physics·E M ChevlenI Elsebai
Jan 28, 1978·British Medical Journal·A K Sim, A P McCraw
Jul 1, 1976·Archives of Biochemistry and Biophysics·J DarsieR T Holman
Jan 1, 1976·Urologia Internationalis·O Parkash, H Kiesswetter
Jan 1, 1975·Biochemical Society Transactions·D A Hall, P E Burdett
Jan 1, 1992·Nutrition and Cancer·J E VenaG Sufrin
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B F FermorN A Habib
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A GonzálezE Riboli
Sep 9, 1991·International Journal of Cancer. Journal International Du Cancer·E RiboliA Agudo
Sep 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P S PrabhaG Ramesh
Jan 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Lundin-Schiller, M D Mitchell
Jan 1, 1990·Annual Review of Nutrition·V A Ziboh, C C Miller
Mar 1, 1990·The British Journal of Surgery·J P Neoptolemos
May 29, 1987·Biochemical and Biophysical Research Communications·U N DasD F Horrobin
Apr 1, 1972·The Journal of Cell Biology·F J ChlapowskiL A Staehelin
Jun 22, 1973·Biochimica Et Biophysica Acta·B KettererD Beale
Apr 1, 1974·The Journal of Cell Biology·J VergaraH Elrod
Jan 1, 1970·Advances in Lipid Research·M Guarnieri, R M Johnson
Jul 1, 1965·The Journal of Cell Biology·R M Hicks
Jan 1, 1981·Progress in Lipid Research·J F Mead
Aug 1, 1980·Annals of Internal Medicine·T A GonwaV M Buckalew
Oct 9, 1995·International Journal of Cancer. Journal International Du Cancer·V ChajèsP Bougnoux
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J R Hebert, D R Miller
Oct 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R A SilvaA R Evnard
Jun 1, 1953·The Journal of Nutrition·J KRAMAR, V E LEVINE
Dec 18, 1954·Lancet·J E NYROP
Nov 1, 1958·The American Journal of Clinical Nutrition·R B ALFIN-SLATER, S BERNICK
Jan 1, 1961·Physiological Reviews·E AAES-JORGENSEN
Dec 2, 1961·JAMA : the Journal of the American Medical Association·R T HOLMAN
Nov 1, 1963·Cancer·E L WYNDERN MANTEL

❮ Previous
Next ❯


Apr 8, 1998·Nutrition·R C Cantrill, Y S Huang
Jul 19, 2013·BioMed Research International·Belmiro ParadaFrederico Teixeira
Oct 27, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D C CremonezziA R Eynard
May 11, 2005·Molecular and Cellular Biochemistry·Guillermina A BongiovanniReyna O Calderón
Jan 25, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Adriana B ActisMirta A Valentich

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.