Is the risk of urinary tract tumorigenesis enhanced by a marginal chronic essential fatty acid deficiency (EFAD)?

Nutrition
Aldo R Eynard

Abstract

A considerable amount of experimental, clinical and epidemiological data indicate that dietary fats play a role in urinary tract tumorigenesis. In rodents, chronic essential fatty acid (EFA) deficiency seems to induce both urolithiasis and transitional hyperplasias, followed by a tendency for tumorigenesis of the urinary passages. High intake of saturated fats or non-EFAs, conditions that may induce EFA deficiency (EFAD) increase the risk of bladder cancer in case-control studies. In other cell populations, EFAs are beneficial as preventive and therapeutic nutrients for the treatment of cancer. Thus, it is reasonable to assume that abnormal metabolism and/or nutritional deprivation of EFA, by inducing a chronic or a subclinical EFA deficiency, may enhance the risk of urothelial tumorigenesis.

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Citations

Apr 8, 1998·Nutrition·R C Cantrill, Y S Huang
Jul 19, 2013·BioMed Research International·Belmiro ParadaFrederico Teixeira
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Jan 25, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Adriana B ActisMirta A Valentich

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