Is the role of human female reproductive tract microbiota underestimated?

Beneficial Microbes
D Kamińska, M Gajecka

Abstract

An issue that is currently undergoing extensive study is the influence of human vaginal microbiota (VMB) on the health status of women and their neonates. Healthy women are mainly colonised with lactobacilli such as Lactobacillus crispatus, Lactobacillus jensenii, and Lactobacillus iners; however, other bacteria may be elements of the VMB, particularly in women with bacterial vaginosis. The implementation of culture-independent molecular methods in VMB characterisation, especially next-generation sequencing, have provided new information regarding bacterial diversity in the vagina, revealing a large number of novel, fastidious, and/or uncultivated bacterial species. These molecular studies have contributed new insights regarding the role of bacterial community composition. In this study, we discuss recent findings regarding the reproductive tract microbiome. Not only bacteria but also viruses and fungi constitute important components of the reproductive tract microbiome. We focus on aspects related to the impact of the maternal microbiome on foetal development, as well as the establishment of the neonatal microbiomes, including the placenta microbiome, and the haematogenous source of intrauterine infection. We also discuss whet...Continue Reading

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Citations

Sep 11, 2018·Frontiers in Immunology·Signe Altmäe
Jul 3, 2020·Frontiers in Public Health·Rashmi Bagga, Parul Arora
Jul 29, 2020·Frontiers in Veterinary Science·Juan J QueredaEmpar García-Roselló
Oct 31, 2020·Frontiers in Cellular and Infection Microbiology·Alexandra A WolfarthRheinallt M Jones
Jul 3, 2021·International Journal of Molecular Sciences·Michał SmoleńskiKatarzyna Małolepsza-Jarmołowska
Oct 6, 2021·Pharmacology Research & Perspectives·María Elena Fátima Nader-MacíasJessica Alejandra Silva

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