Is the seric eosinophil cationic protein level a valuable tool of diagnosis in clinical practice?

La Revue de médecine interne
D A Moneret-Vautrin

Abstract

The eosinophil cationic protein (ECP) is one of the mediators released during eosinophil activation. These cells are effector cells taking part into the Th2-lymphocyte dependent allergic inflammation. Assaying ECP concentrations in blood and sputum may be useful in evaluating allergic inflammation (asthma and rhinitis). This summary considers the value of measuring ECP levels for the diagnosis of various diseases where an eosinophil-mediated tissue inflammation plays a role. Levels of eosinophil cationic protein have been determined in nasal secretions, sputum, gastric secretions, feces and serum. They are increased during seasonal allergic rhinitis and perennial rhinitis, allergic asthma and atopic dermatitis. They are also increased in various gastro-intestinal disorders, some of which are associated with IgE: eosinophil intestinal diseases (esophagitis, gastro-enteritis and colitis), gastro-intestinal food allergy and intestinal parasitoses. Finally, they are increased in non IgE-dependent disorders: non allergic asthma with aspirin intolerance, respiratory infections, sinonasal polyposis, Churg-Strauss disease and idiopathic hyper-eosinophilia (HES) syndrome. Assaying serum ECP could help in the diagnosis of several disease...Continue Reading

References

Jan 1, 1994·British Journal of Haematology·M CarlsonP Venge
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·M TomassiniS Bonini
Jul 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M L KowalskiM Poniatowska
May 29, 1998·The British Journal of Ophthalmology·A HeiligenhausK P Steuhl
May 4, 1999·International Archives of Allergy and Immunology·C BachertP Van Cauwenberge
May 8, 1999·The European Respiratory Journal·C LemièreF E Hargreave
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H MajamaaA Miettinen
Oct 12, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·C J Pronk-AdmiraalP C Bartels
Nov 9, 2000·American Journal of Rhinology·C BachertP van Cauwenberge
Oct 17, 2001·Respiratory Medicine·H MezianeP Chanez
Feb 16, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Y NagayamaO Kiyofumi
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J MeijerH A M Kerstjens
Jul 30, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Kristiina Mertta SaarinenErkki Savilahti
Oct 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M van Hage-HamstenR Grönneberg
Dec 31, 2002·The European Respiratory Journal·M RomagnoliP Chanez
Jul 10, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J Domínguez-OrtegaC Martínez-Cócera
Aug 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J MagnussonC G B Peterson
Dec 17, 2003·Allergy·P Venge
Aug 13, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Karin LönnkvistMagnus Svartengren
Jan 15, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·A Selnes, L K Dotterud

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Citations

Feb 23, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Vittoria PeonaGiorgio Ciprandi
Nov 5, 2013·Expert Review of Anti-infective Therapy·Coralie L'Ollivier, Renaud Piarroux
Apr 28, 2009·La Revue de médecine interne·J-C EicherJ-E Wolf
May 22, 2008·Best Practice & Research. Clinical Gastroenterology·Sébastien Conus, Hans-Uwe Simon
Aug 2, 2016·Journal of Clinical Gastroenterology·Steve B MinFouad J Moawad
Apr 2, 2019·Allergy·Yanaika S Sabogal PiñerosRené Lutter
Nov 30, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S BerthetS Destombe

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