Is the Sexual Behaviour of HIV Patients on Antiretroviral therapy safe or risky in Sub-Saharan Africa? Meta-Analysis and Meta-Regression.

AIDS Research and Therapy
Asres Berhan, Yifru Berhan

Abstract

Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. We included both cross-sectional studies that compared different ART-naïve and ART-experienced participants and longitudinal studies examining the behavior of the same individuals pre- and post-ART start. Meta-analyses were performed both stratified by type of study and combined. Outcome variables assessed for association with ART experience were any sexual activity, unprotected sex and having multiple sexual partners. Random-effect models were applied to determine the overall odds ratios. Sub-group analyses and meta-regression analyses were performed to examine sources of heterogeneity among the studies. Sensitivity analysis was also conducted to evaluate the stability of the overall odds ratio in the presence of outliers. The meta-analysis failed to show a statistically significant association of any sexual activity with ART experience. It did, however, show an overall statistically significant reduction of any unprotected sex, having multiple sexual partners and unprotected sex with HIV negative or unknown HIV status with ART exp...Continue Reading

References

Apr 20, 2002·Journal of Epidemiology and Community Health·A-D BouhnikUNKNOWN MANIF 2000 Study Group
Jul 12, 2002·Statistics in Medicine·Jeroen G LijmerSiem H Heisterkamp
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Oct 10, 2003·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Kerstin E E SchroderPeter A Vanable
Oct 21, 2003·AIDS·Jean-Paul MoattiUNKNOWN Côte d'Ivoire HIV Drug Access Initiative Socio-Behavioural Evaluation Group
Jul 1, 2004·American Journal of Public Health·Tracey E WilsonStephen J Gange
Jul 14, 2004·JAMA : the Journal of the American Medical Association·Nicole CrepazGary Marks
Feb 9, 2005·American Journal of Health Behavior·Marguerita LightfootRobert Weiss
Aug 10, 2006·JAMA : the Journal of the American Medical Association·Edward J MillsDavid R Bangsberg
Dec 20, 2007·AIDS·Souleymane DiabatéConstance Kanga Koffi
Jan 16, 2008·Archives of Internal Medicine·Lara R FairallRonald D Chapman
Jul 8, 2008·AIDS Patient Care and STDs·Stanley LuchtersMarleen Temmerman
Dec 8, 2009·BMC Medical Research Methodology·Byron C WallaceThomas A Trikalinos
Nov 18, 2010·AIDS and Behavior·Cynthia R PearsonStephen S Gloyd
Jan 22, 2011·AIDS·Leigh Anne ShaferDermot Maher
Apr 19, 2011·Journal of the International AIDS Society·Anders RagnarssonAnna Thorson
Jun 2, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M O OsindeO Kakaire
May 1, 2008·African Journal of AIDS Research : AJAR·Benjamin O Olley

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Citations

Jun 29, 2013·AIDS Research and Therapy·Wing Young Nicola ManPeter M Siba
May 18, 2016·Indian Journal of Sexually Transmitted Diseases and AIDS·Mukesh ShuklaVijay Kumar Singh
Jul 22, 2015·AIDS and Behavior·Kathryn RisherDavid D Celentano
Dec 10, 2014·AIDS and Behavior·Adebola A AdedimejiKathryn Anastos
Nov 29, 2012·Current Opinion in HIV and AIDS·Reuben GranichJulio Montaner

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