Is the survival of melanoma patients receiving polyvalent melanoma cell vaccine linked to the human leukocyte antigen phenotype of patients?

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Dave S B HoonDonald L Morton

Abstract

An allogeneic polyvalent melanoma cell vaccine (PMCV) has been shown to be efficacious in improving overall survival of patients with malignant melanoma in a phase II clinical setting. The PMCV consists of three allogeneic melanoma cell lines. The objectives of the study were to determine (1) whether the survival of melanoma patients who received PMCV was related to the patient's human leukocyte antigen (HLA) class I phenotype matching the HLA class I phenotype of the PMCV, and (2) whether PMCV clinical efficacy was correlated to melanoma patients with a particular HLA phenotype(s). PMCV was given to 69 melanoma patients with American Joint Committee on Cancer (AJCC) stage I to IV disease status. The PMCV and patients lymphocytes were typed for HLA-A and -B. A correlation was made between the HLA expression of PMCV lines and the HLA of patients to their survival status. A second correlation was made between the HLA of patients and survival independent of the PMCV HLA phenotype. Patients whose HLA phenotype (A3/11 and B7/44) matched the PMCV lines had a better overall survival (P < .029). Analysis of HLA expression of patients independent of PMCV HLA to survival showed that HLA-A25 phenotype patients had a significantly better o...Continue Reading

Citations

Jan 20, 2012·Cancer Immunology, Immunotherapy : CII·Emilia AnderssonGiuseppe V Masucci
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J BostickD S Hoon
May 30, 2003·Seminars in Cutaneous Medicine and Surgery·Hassane M Zarour, John M Kirkwood
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A SosmanUNKNOWN Southwest Oncology Group
Jan 25, 2000·Cancer Treatment Reviews·T A Plunkett, D W Miles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.