Is the variation in the susceptibility of various species to atherosclerosis due to inborn differences in prostacyclin (PGI2) formation

Experientia
H SinzingerM Winter

Abstract

Species exhibiting a higher susceptibility to the development of atherosclerosis have a reduced prostacyclin (PGI2)-generation in the arterial wall, which differs in various parts of the vascular system. As the difference in PGI2-formation in various diseases is a generalized vascular effect, the changes can be detected in all vessels. This is a very important point for diagnostic purposes in humans.

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Citations

May 1, 1981·Prostaglandins·M ClaeysD H Nugteren
Jan 1, 1987·Pharmacology & Therapeutics·R J MorinS K Peng
Feb 1, 1997·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·G R UpchurchG Johnson
Jul 8, 2011·Journal of the Royal Society, Interface·Deshun Lu, Ghassan S Kassab
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Sep 1, 1988·Pharmacological Research Communications·H Sinzinger
May 16, 2013·Phytotherapy Research : PTR·Ciddi VeereshamKaleab Asres
Aug 1, 1983·The Journal of Surgical Research·M D KersteinD B McNamara

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