DOI: 10.1101/19002584Nov 25, 2019Paper

Is therapeutic inertia present in primary diabetes care in Malaysia? A prospective study

MedRxiv : the Preprint Server for Health Sciences
BOON HOW CHEWZ. Akthar Supian


Aims: This prospective study aimed to determine the proportions of therapeutic inertia when treatment targets not achieved in adults T2D at three public health clinics in Malaysia. Methods: The index prescriptions were those when the annual blood tests were reviewed. Prescriptions were verified and classified as 1) no change, 2) stepping up and 3) stepping down. Multivariable logistic regression and sensitive analyses were conducted. Results: At follow-up, 552 participants were available for the assessment of therapeutic inertia (78.9% response rate). The mean (SD) age and diabetes duration were 60.0 (9.9) years and 5.0 (6.0) years, respectively. High therapeutic inertia were observed in oral anti-diabetic (61-72%), anti-hypertensive (34-65%) and lipid-lowering therapies (56-77%), and lesser in insulin (34-52%). Insulin therapeutic inertia was more likely among those with shorter diabetes duration (adjusted OR 0.9, 95% CI 0.87, 0.98). Those who did not achieve treatment targets were less likely to experience therapeutic inertia: HbA1c [≥] 7.0%: adjusted OR 0.10 (0.04, 0.24); BP [≥] 140/90 mmHg: 0.28 (0.16, 0.50); LDL-cholesterol [≥] 2.6 mmol/L: 0.37 (0.22, 0.64). Conclusions: Although therapeutic intensifications were ...Continue Reading

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