Is there a clinical correlate to the histologic evidence of inflammation in herniated lumbar disc tissue?

Spine
R D RothoerlA Brawanski

Abstract

The presence of inflammatory cells was examined immunohistochemically in routinely processed resection specimens of the lumbar disc. The histologic results were compared with prospectively obtained clinical data. To assess the clinical relevance of inflammatory cells in herniated lumbar disc specimens. It is postulated that in addition to nerve root compression, an inflammatory stimulus of the herniated lumbar disc is responsible for sciatic pain and radiculopathy. However, the clinical relevance of the histologically described inflammatory infiltrates is not defined clearly. Disc specimens from 44 patients who underwent surgery for lumbar disc herniation were studied immunohistologically. Before surgery, severity of pain was classified in each patient according to a visual analog scale, and general clinical data were recorded prospectively. Varying amounts of inflammatory cells could be demonstrated in the resected disc tissue. In the statistical analysis, no statistically significant correlation between the histologic evidence of macrophage infiltrates and the pain grading scale or the clinical data was noted. There is no statistically significant correlation between macrophage infiltrates in herniated lumbar disc specimens a...Continue Reading

References

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Citations

Feb 14, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·A Cüneyt OzaktayJames N Weinstein
Jun 6, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Tõnu RätsepToomas Asser
May 27, 2005·Neurosurgical Focus·Michael D MartinDavid G Malone
Jun 4, 2008·Journal of Neurosurgery. Spine·Daniel HaschtmannJivko V Stoyanov
Oct 18, 2005·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yoshihiro SakamotoKatsumasa Takagi
Feb 27, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ralf Dirk RothoerlAlexander Brawanski
Aug 31, 2019·Journal of Clinical Medicine·Jon FordMatthew Richards
Jul 25, 2000·Clinical Orthopaedics and Related Research·M KawakamiM Shinozaki
Nov 27, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·N DjuricC L A Vleggeert-Lankamp
Aug 15, 2019·Arthritis Research & Therapy·Eivind HasvikJohannes Gjerstad

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