Is there a clinical relevance of partial androgen deficiency of the aging male?

The Journal of Urology
Mirjam Christ-CrainChristian Meier

Abstract

Aging in men is characterized by a progressive, generally moderate decrease in plasma testosterone (T) levels and T substitution is increasingly prescribed. However, the association of partial androgen deficiency of the aging male with clinical symptoms and the ideal screening test are controversial. We investigate the association between various T measures and clinical and biochemical parameters of the aging male. We investigated the association between total (TT), calculated free (FTcalc) and bioavailable (BT) testosterone, and various clinical and biochemical parameters in 51 healthy community living male volunteers, 55 and 75 years old. The parameters included serum levels of sex hormone-binding globulin, estradiol and lipid profile after an overnight fast; questionnaires assessing clinical symptoms, erectile function and mood; bone mineral density and body composition. TT correlated with FTcalc (r2 = 0.71, p <0.001) but not with BT (r2 = 0.04, p not significant) and FTcalc correlated moderately with BT (r2 = 0.23, p <0.001). Testicular volume correlated with TT levels (r2 = 0.17, p <0.001) and FTcalc (r2 = 0.17, p <0.001) but not with BT. There was neither a correlation of TT, FTcalc nor BT values with clinical symptoms no...Continue Reading

References

Feb 1, 1985·Biological Psychiatry·J A YesavageP A Berger
Jul 1, 1983·The Journal of Clinical Endocrinology and Metabolism·J M DavidsonJ A Catania
Nov 1, 1995·Progress in Cardiovascular Diseases·C J Bagatell, W J Bremner
Oct 1, 1996·The Journal of Clinical Endocrinology and Metabolism·C WangR S Swerdloff
Jun 1, 1997·The Journal of Clinical Endocrinology and Metabolism·W Rosner
Nov 14, 1997·The Journal of Clinical Endocrinology and Metabolism·R R HajjarJ E Morley
Jun 24, 1998·Psychopathology·P RichterH Sauer
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·E Barrett-ConnorD J Sartoris
Feb 25, 2000·Maturitas·A Vermeulen
Oct 4, 2000·Metabolism: Clinical and Experimental·J E MorleyH M Perry
Apr 30, 2002·Metabolism: Clinical and Experimental·John E MorleyH M Perry
Nov 25, 2003·The Journal of Urology·Akira TsujimuraAkihiko Okuyama

❮ Previous
Next ❯

Citations

Nov 4, 2006·World Journal of Urology·Jacques Buvat, Gilbert Bou Jaoudé
Jun 4, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Hua YangAbass Alavi
Jun 15, 2011·Biological Trace Element Research·Chung Soo ChangSat Byul Park
Jun 1, 2005·European Urology·M E BeutelUNKNOWN Hypogonadism Investigator Group
Mar 23, 2011·Asian Journal of Andrology·Balasubramanian Srilatha, P Ganesan Adaikan
Jul 8, 2008·Nature Clinical Practice. Urology·Jacques L Tostain, François Blanc
Aug 27, 2005·International Journal of Impotence Research·T I-S HwangH-E Chen
Nov 18, 2005·International Journal of Impotence Research·Y C LinS P Huang
Feb 29, 2008·International Journal of Impotence Research·T I S Hwang, Y-C Lin
Sep 28, 2005·Treatments in Endocrinology·Emily Darby, Bradley D Anawalt
Sep 21, 2010·Human Fertility : Journal of the British Fertility Society·Kevan Wylie, Natalie Froggatt
May 15, 2007·The Journal of Sexual Medicine·Wael ZohdyYasser Ibrahim
May 10, 2006·The Journal of Sexual Medicine·Abdulmaged M Traish, André T Guay
May 3, 2006·The American Journal of Medicine·Nasser Mikhail
Feb 7, 2009·Arquivos brasileiros de endocrinologia e metabologia·Ruth ClapauchYolanda Schrank
Apr 6, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Bruno Felix-PatrícioFrancisco J B Sampaio
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·M Christ-CrainB Mueller
Oct 5, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro MaedaMototsugu Oya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.