Is there a correlation between follicle size and gene expression in cumulus cells and is gene expression an indicator of embryo development?

Reproductive Biology and Endocrinology : RB&E
Semra KahramanMarkus Montag

Abstract

In an article published in 2017, we discussed the results of the first part of our study into the morphokinetic development of embryos in relation to follicle diameter and homogeneity of follicular development. Our findings showed that embryos coming from small follicles in heterogeneous cycles had significantly higher rates of arrest or failure to reach blastocyst than embryos coming from large follicles in homogenous cycles. The aim of this further study was to investigate the relationship between follicular size and gene expression of cumulus cells (CCs) and evaluate whether gene expression could be an indicator of embryo development. This study was based on 2495 COCs from 184 patients. CC expressions of five genes (TNFAIP6, PTGS2, HAS2, PTX3 and GDF9) were studied by generalized linear mixed models (GLMMs) regarding follicular size. CC expressions were then separately analysed regarding patient-specific variables (age, BMI, AMH and follicular size) in relation to embryos reaching blastocyst (eRB) or top or good quality blastocysts (TQ + GQ) using GLMMs with logit link. Follicular size significantly correlated with the potential of an oocyte to develop into a blastocyst: oocytes developing from large follicles were more than...Continue Reading

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Citations

Jun 4, 2019·Molecular Biology Reports·Azita FaramarziMasoumeh Golestan Jahromi
Aug 31, 2019·Animal Science Journal = Nihon Chikusan Gakkaihō·Fabiana Dakkach de Almeida BarrosBruno Cesar Michelette Damião
Sep 5, 2020·Zygote : the Biology of Gametes and Early Embryos·Linda DujíčkováFrantišek Strejček
Jan 28, 2022·Reproductive Sciences·Laís R F M PaulinoJosé R V Silva

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Methods Mentioned

BETA
PCR
dissection

Clinical Trials Mentioned

NCT02230449

Software Mentioned

NCSS ( Number Cruncher Statistical System )

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