Is there a difference between strong ion gap in healthy volunteers and intensive care unit patients?

Journal of Critical Care
Kyle J GunnersonJohn A Kellum

Abstract

Abnormalities of strong ion gap (SIG) are common in critically ill intensive care unit (ICU) patients in conjunction with a high incidence of acid-base abnormalities. However, it is unknown whether abnormalities in SIG are also seen in ICU patients without active acid-base abnormalities. Thus, we conducted this pilot study to examine differences in quantitative acid-base variables between healthy adult volunteers and stable ICU patients with no suspected acid-base abnormalities. The study used a prospective observational study of 2 cohorts, 15 healthy adult volunteers and 15 stable adult patients just before ICU discharge who were not receiving renal replacement therapy and had no known active acid-base derangements. We analyzed venous blood for acid-base variables (potential hydrogen in central venous blood [pH(CV)], partial tension of carbon dioxide in central venous blood [p(CV)co(2)], standard base excess [SBE], lactate, Na(+), K(+), Cl(-), Mg(2+), Ca(2+), phosphate, and albumin). From these, we calculated strong ion difference (SID) and SIG for both cohorts. Although mean values for pH(CV), p(CV)CO(2), and SBE were within the normal range in both cohorts, 10 (66.7%) of 15 of ICU patients were found to have occult acid-base...Continue Reading

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Citations

Aug 6, 2013·Journal of Critical Care·Miriam MoviatPeter Pickkers
Nov 26, 2010·Journal of Critical Care·Gildas GueretJean-Luc Carre
Sep 13, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammed Al-Jaghbeer, John A Kellum
Mar 23, 2005·Critical Care Clinics·John A Kellum
Aug 28, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Ashish Verma, Rehan Qayyum
Oct 17, 2020·International Journal of Nephrology and Renovascular Disease·Ozgur KilicSelcuk Yazici

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