PMID: 2500232Jul 15, 1989Paper

Is there a direct differentiation-inducing effect of human recombinant interferon on hairy cell leukemia in vitro?

Cancer
V H GresslerH M Golomb

Abstract

We used a panel of monoclonal antibodies (moAb) to label splenic hairy cells from eight patients to determine the membrane phenotypes, the presence of cytoplasmic immunoglobulin (cIg), and the expression of maturation-associated antigens. All eight patients had responded clinically to splenectomy either alone or in combination with alpha-2b-interferon (alpha-IFN) therapy. For each sample, cytofluorimetric analysis showed distinct, and in six cases multiple, heavy chain isotypes. After short-term culture in the presence of alpha-IFN or gamma-interferon (gamma-IFN), samples from four patients displayed characteristic changes in surface immunoglobulin (sIg) expression. When compared with untreated cells, cells co-cultured with alpha-IFN or gamma-IFN showed in four and three patients, respectively, changes that were consistent with a shift to the more mature stage in B-cell ontogeny. However, in parallel with the changes in the sIg isotypes, treatment with IFN did not induce the appearance of cIg nor did the staining patterns for moAb to CD5, CD19, CD20, and CD22 antigens indicate the induction of terminal maturation. These data suggest that hairy cell leukemia (HCL), a neoplasm of "mature" B-cells, is potentially susceptible to ma...Continue Reading

References

Dec 1, 1977·Cellular Immunology·I Gresser
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R Michalevicz, M Revel
Mar 1, 1980·European Journal of Immunology·F M Vessière-LouveauxH R Schuit
Jan 1, 1981·The Journal of Membrane Biology·M A Lieberman, L Glaser
Feb 1, 1984·The American Journal of Medicine·R R TubbsJ K Weick
Jan 5, 1984·The New England Journal of Medicine·J R QuesadaJ U Gutterman
Jan 1, 1981·The Journal of Clinical Investigation·L M NadlerP Stashenko
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P StashenkoS F Schlossman
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E G EnglemanR Levy

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.