Is there a genetic susceptibility locus for Parkinson's disease on chromosome 22q13?

Annals of Neurology
K WilhelmsenR Mayeux

Abstract

The cytochrome P450 mono-oxygenase gene, CYP2D6 on chromosome 22q13 (ch22q13), has been inconsistently associated with Parkinson's disease. Associations with CYP2D6 have either been absent altogether or have involved more than one polymorphism, many of which have the same metabolic effect on gene expression. We examined the association between CYP2D6 polymorphisms and Parkinson's disease in a case-control study and included 10 polymorphic dinucleotide repeat markers linked to CYP2D6 to determine whether the association was present or due to linkage disequilibrium. There was no association between any polymorphism of CYP2D6 and Parkinson's disease, but two of 10 dinucleotide repeat markers linked to CYP2D6 were associated with the disease. These results provide evidence to suggest that there may be an unidentified locus for susceptibility to Parkinson's disease that is in linkage disequilibrium with dinucleotide repeat markers mapping near CYP2D6 on ch22q13.

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Mar 1, 1995·Clinical Pharmacology and Therapeutics·J A AgúndezF Coria
Oct 1, 1994·Nature Genetics·G Thomson
Aug 1, 1993·Journal of Biochemistry·Y TsuneokaY Ichikawa
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·I JohanssonM Ingelman-Sundberg
Aug 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·V Planté-BordeneuveA E Harding
Oct 15, 1993·American Journal of Medical Genetics·M C Kurth, J H Kurth
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·U J KimM I Simon
Jul 1, 1996·Neurology·M S SandyJ R Idle

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Citations

Aug 6, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·O JoostR H Myers
Apr 11, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·B S HarhangiM M Breteler
Jun 24, 1998·Clinical Neurology and Neurosurgery·B A VeldmanM W Horstink
Mar 7, 2003·Genomics·Benjamin FletcherMark G Thomas
Sep 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L LaforestK Husgafvel-Pursiainen
Sep 5, 2009·Journal of the American Society of Nephrology : JASN·Minesh KhatriClinton B Wright
May 24, 2012·ISRN Neurology·Khanh L Ng, Lan Nguyễn
Aug 2, 2018·International Journal of Molecular Sciences·Rita MorettiPaola Caruso
Jan 28, 1999·The Journal of Biological Chemistry·J MatsunagaV J Hearing
Apr 18, 1998·Brain Pathology·P G InceC M Morris
Nov 27, 1998·Clinical Genetics·T Gasser

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