PMID: 39641Aug 1, 1979

Is there a limbic system equivalent of tardive dyskinesia?

Biological Psychiatry
K L Davis, G S Rosenberg

Abstract

Long-term administration of antipsychotic drugs to animals induces super-sensitive mesolimbic postsynaptic dopamine receptors. It is possible that a similar process can occur in man. Following a reduction in the dose of antipsychotic medications, or their complete discontinuation, mesolimbic dopamine receptor supersensitivity could be reflected in rapid relapse of schizophrenic patients, the development of schizophrenic symptoms in patients with no prior history of schizophrenia, or in the necessity for ever-increasing doses of long-acting depot fluphenazine to maintain a remission.

Related Concepts

Dose-Response Relationship, Drug
Dyskinesia, Medication-Induced
Lyogen
Limbic System
Midbrain Structure
Neural Pathways
Dopamine Receptor
Schizophrenia
Antipsychotic Effect

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