PMID: 39641Aug 1, 1979

Is there a limbic system equivalent of tardive dyskinesia?

Biological Psychiatry
K L Davis, G S Rosenberg


Long-term administration of antipsychotic drugs to animals induces super-sensitive mesolimbic postsynaptic dopamine receptors. It is possible that a similar process can occur in man. Following a reduction in the dose of antipsychotic medications, or their complete discontinuation, mesolimbic dopamine receptor supersensitivity could be reflected in rapid relapse of schizophrenic patients, the development of schizophrenic symptoms in patients with no prior history of schizophrenia, or in the necessity for ever-increasing doses of long-acting depot fluphenazine to maintain a remission.

Related Concepts

Dose-Response Relationship, Drug
Dyskinesia, Medication-Induced
Limbic System
Midbrain Structure
Neural Pathways
Dopamine Receptor
Antipsychotic Effect

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.