Is there a link between changes in the vertebral "hox code" and the shape of vertebrae? A quantitative study of shape change in the cervical vertebral column of mice

Journal of Theoretical Biology
D R Johnson, P O'Higgins

Abstract

Homeobox (hox) genes are of considerable importance in the formation of the body axis of invertebrates and vertebrates. The postulation of a hox-code (i.e. the simultaneous activity of a certain subset of hox genes) for structures at different metameric levels and which differ from each other in shape suggests a relationship between hox-code and shape, which is reinforced by the possibility of homeotic transformation when the hox-code is changed experimentally. This paper considers the possible nature of such a relationship between the hox genes governing vertebral formation in the upper part of the mouse vertebral column and the shape of the adult vertebrae formed in this region.

Citations

Mar 22, 2016·Royal Society Open Science·Megu Gunji, Hideki Endo
Jun 19, 2015·Proceedings. Biological Sciences·Christine BöhmerGert Wörheide
Mar 23, 2017·Evolution; International Journal of Organic Evolution·Patrick ArnoldMartin S Fischer
Nov 26, 2008·Zoology : Analysis of Complex Systems, ZACS·Nathan C Bird, L Patricia Hernandez
Jan 24, 2018·Evolution; International Journal of Organic Evolution·Catalina I Villamil
May 16, 2007·Evolution & Development·Emily A Buchholtz
Feb 7, 2009·Evolution & Development·Emily A Buchholtz, Courtney C Stepien
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Oct 26, 2005·Fetal and Pediatric Pathology·Alan William Bates, Krsty Nale

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