Oct 16, 1999

Is there a maternally induced immunological imprinting phase à la Konrad Lorenz?

Scandinavian Journal of Immunology
H Lemke, H Lange

Abstract

In mammals, IgG antibodies are transferred from mothers to the offspring. Since these maternal antibodies result mainly from thymus-dependent immune responses which have undergone immune maturation through somatic hypermutations, they represent the highest quality of the collective maternal immunological experience. Maternal antibodies not only confer passive immunity as long as the newborn's immune system has not fully developed, but also exert an active stimulation as indicated by their regulatory influence on isotype expression, long-term idiotypic alterations, determination of the adult B and T cell repertoire, induction of antigen reactive IgM as well as an affinity enhancement of a proportion of early primary antibodies. The fact that several of these features can only be induced during limited sensitive periods shortly after birth is reminiscent of the behavioural imprinting as defined by Konrad Lorenz. We therefore propose that during early ontogeny there is an immunological imprinting phase with characteristics analogous to behavioural imprinting: (i) the internal imprinting effect is induced by external signals, (ii) in contrast to normal learning, immunological imprinting is also only possible during certain developm...Continue Reading

Mentioned in this Paper

Immune Response
Immune System
T-Lymphocyte
Exertion
Passive immunity [no drugs here]
Neoplasm of Uncertain or Unknown Behavior of Thymus
Disease of Thymus Gland
Biologic Development
Neonatal Immunity, Maternally-Acquired
Immunoglobulin Isotypes

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