Is there a need for neoadjuvant short-course radiotherapy in T3 rectal cancer with positive lymph node involvement? A single-center retrospective cohort study

World Journal of Surgical Oncology
Minna RäsänenAnna Lepistö

Abstract

Neoadjuvant short-course radiotherapy is used to reduce local recurrences in stage III rectal cancer. Radiotherapy is not harmless, and meticulous total mesorectal excision surgery alone has been reported to result in low local recurrence rate in favorable stage III tumors. The aim was to evaluate the effect of short-course (5 × 5 Gy) radiotherapy on the local recurrence risk in patients with pT3N1-2 rectal cancer. This was a retrospective study with 151 consecutive pT3N1-2M0 rectal cancer patients operated on at Helsinki University Hospital, Helsinki, Finland, during January 2005 to June 2014. Short-course radiotherapy was given to 94 patients, and 57 patients were operated on without neoadjuvant radiotherapy. The main outcome measurement was the effect of radiotherapy on local recurrence. Also, the risk factors for local recurrence were analyzed. Local recurrence occurred in a total 17 of 151 (11.3%) patients, 8 of 57 (14.0%) in surgery only group compared with 9 of 94 (9.6%) in radiotherapy plus surgery group (p = 0.44). In univariate Cox regression analysis, the risk factors for local recurrence were tumor location under 6 cm from the anal verge (p = 0.01), involved lateral margin (p < 0.001), tumor perforation (p < 0.001),...Continue Reading

References

Oct 1, 1982·The British Journal of Surgery·R J HealdR D Ryall
Feb 20, 1993·Lancet·J K MacFarlaneR J Heald
Apr 3, 1997·The New England Journal of Medicine·UNKNOWN Swedish Rectal Cancer TrialN Wilking
Sep 8, 2001·The New England Journal of Medicine·E KapiteijnUNKNOWN Dutch Colorectal Cancer Group
Nov 1, 2001·International Journal of Colorectal Disease·S MerkelP Hermanek
Aug 23, 2002·The British Journal of Surgery·E KapiteijnUNKNOWN Cooperative investigators of the Dutch ColoRectal Cancer Group
Nov 4, 2004·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P MatthiessenR Sjödahl
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Corrie A M MarijnenAnne M Stiggelbout
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joakim FolkessonUlf Gunnarsson
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helgi BirgissonBengt Glimelius
Feb 9, 2006·British Journal of Cancer·S BurtonUNKNOWN Royal Marsden Hospital, Colorectal Cancer Network
Dec 21, 2006·Diseases of the Colon and Rectum·Morten T EriksenUNKNOWN Norwegian Rectal Cancer Group
Jan 26, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M KustersG L Beets
Jun 1, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T E BernsteinUNKNOWN Norwegian Colorectal Cancer Registry
Dec 3, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C B M van den BroekUNKNOWN EURECCA Consortium
Mar 23, 2015·International Journal of Colorectal Disease·Minna RäsänenAnna Lepistö
Jul 30, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P BondevenB G Pedersen

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
dissection
irradiate

Software Mentioned

StatExact
SPSS
Cytel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Diseases of the Colon and Rectum
Guillaume MartelRobin P Boushey
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Aviram NissanW Douglas Wong
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
A Reig CastillejoM Algara
© 2021 Meta ULC. All rights reserved