PMID: 11899189Mar 20, 2002Paper

Is there a place for preconditioning during cardiac operations in humans?

The Annals of Thoracic Surgery
Bruno PouzetP Menasché

Abstract

Activation of the kinase cascade (protein kinase C (PKC), tyrosine kinase (TK), and mitogen-activated protein kinase (MAPK) is a key feature of the transduction pathway, elicited by preconditioning signals and mediating their cardioprotective effects. We assessed whether such an activation occurred during cardiac operations and could thus represent a target for cardioprotective strategies. A total of 20 patients undergoing coronary artery bypass grafting surgery were studied. During the first 10 minutes of cardiopulmonary bypass (CPB), 10 were treated with sevoflurane (2.5 minimum alveolar concentration), an inhalational anesthetic that mimics preconditioning through a similar activation of the kinase cascade. Ten case-matched patients undergoing 10 minutes of sevoflurane-free CPB served as controls. Right atrial biopsies were taken before and 10 minutes after CPB and were then processed for the measurement of PKC, TK, and p38 MAPK activities by enzyme assay techniques. Troponin I was also monitored over the first 2 postoperative days. Compared with pre-CPB values, PKC and p38 MAPK activities (in nanomoles per milligram of protein per minute and arbitrary units, respectively) increased significantly and to the same extent in bo...Continue Reading

References

Jul 27, 1992·Biochimica Et Biophysica Acta·L TremblayR Béliveau
Jan 1, 1991·Methods in Enzymology·B E Kemp, R B Pearson
Jan 1, 1997·Journal of Molecular and Cellular Cardiology·C P BainesJ M Downey
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·T IshizukaE W Gelfand
Mar 17, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S ConradieJ Coetzee
May 11, 1999·Annals of Surgery·R M MentzerR D Lasley
Nov 24, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B PreckelW Schlack
Aug 5, 2000·The Journal of Thoracic and Cardiovascular Surgery·B J PomerantzA H Harken
Sep 2, 2000·The Annals of Thoracic Surgery·D BelhommeP Menasché
Sep 2, 2000·The Annals of Thoracic Surgery·G R GaudetteS Levitsky
Nov 14, 2000·Circulation Research·B O'Rourke
Mar 30, 2001·The Journal of Thoracic and Cardiovascular Surgery·E G AraujoF W Sellke

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Citations

Sep 9, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chun Hua Yu, W Scott Beattie
Feb 22, 2005·Basic Research in Cardiology·Guro Valen, Jarle Vaage
Mar 20, 2003·The Annals of Thoracic Surgery·Ulrich SunderdiekJochen D Schipke
Jun 9, 2009·British Journal of Anaesthesia·J FrässdorfW Schlack
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Stefan G De Hert
May 26, 2009·The Journal of Thoracic and Cardiovascular Surgery·Jan FrässdorfWolfgang Schlack
May 23, 2008·Best Practice & Research. Clinical Anaesthesiology·Yon Hee Shim, Judy R Kersten
Aug 7, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniGiorgio Torri
Jan 15, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Matti R Tarkka
Aug 4, 2006·Journal of Cardiothoracic and Vascular Anesthesia·Stefan G De Hert
Jun 11, 2015·Best Practice & Research. Clinical Anaesthesiology·Stefan De Hert, Anneliese Moerman
Jun 1, 2005·Vascular Pharmacology·Martin W BienengraeberDavid C Warltier
Jun 3, 2008·Asian Cardiovascular & Thoracic Annals·Suraphong LorsomradeeStefan G De Hert
Apr 28, 2004·Anesthesiology·Katsuya TanakaDavid C Warltier
May 17, 2006·Seminars in Cardiothoracic and Vascular Anesthesia·Stefan G De Hert
Oct 28, 2009·Anesthesiology·Lixin LiuMario J Rebecchi
Aug 1, 2009·European Journal of Anaesthesiology·Stefan G De HertWolfgang S Schlack
Jan 1, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Jiang ZhuLixin Liu
Apr 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Zlatina NaydenovaImogen R Coe
May 28, 2005·Anesthesia and Analgesia·Stefan G De HertDavid F Stowe
Apr 29, 2006·Journal of Cardiovascular Medicine·Luca SiracusanoNunziata Di Marco Chiavarino
Oct 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Irina ShuralyovaImogen R Coe

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