Is there a relation between duration of cyclosporine usage and right and left ventricular function in renal transplant patients? Tissue Doppler Echocardiography study

Transplantation Proceedings
Huseyin OflazMehmet Sukru Sever

Abstract

Our aim was to investigate the effect of cyclosporine (CsA), which is commonly used in renal transplant patients and causes myocardial fibrosis and elevated arterial tension, on cardiac function. Sixty-six renal transplant patients (RTPs) and 25 healthy controls were included in the study. Renal transplantation patients were divided according to time of CsA exposure: group 1 (0 to 36 months); group 2 (36 to 72 months) and group 3 (> 72 months). Systolic peak velocity (Sm, mitral; St, tricuspid) and mitral early (e)/late (a) (Me/a) and tricuspid e/a (Te/a) waves of the right and the left ventricles were measured by pulse-wave (PW) Doppler used for tissue Doppler imaging of both ventricles as well as the ventricle free wall near to the lateral tricuspid and the posterior mitral leaflets. The measurements included conventional diastolic early (E) and late (A) waves and deceleration time (DT) of the E wave, isovolumetric relaxation time (IVRT) of both ventricles, as well as left ventricular systolic ejection fraction (EF). There were no statistically significant differences between the groups with regard to demographic, clinical, and most biochemical characteristics. Left ventricular EF was normal in all groups; there were no stati...Continue Reading

References

Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A S Levey
Sep 27, 2000·Journal of the American Society of Nephrology : JASN·Stephen G Rostand
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M AnnukB Fellström
Oct 5, 2001·Transplantation·H A Koomans, G Ligtenberg
Nov 15, 2002·Transplantation Proceedings·A TürkmenM S Sever
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alaattin YildizMehmet S Sever

❮ Previous
Next ❯

Citations

Apr 1, 2007·Pakistan Journal of Biological Sciences : PJBS·I M GhasemiM Izadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

© 2022 Meta ULC. All rights reserved