Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?

European Journal of Internal Medicine
I MikolasevicL Orlic

Abstract

We investigated the association among long-term proton-pump inhibitors (PPIs) use with serum magnesium (Mg) levels in chronic hemodialysis (HD) patients, as well as possible association among PPI use and increased risk of cardiovascular (CVD) morbidity in HD patients. Of 418 HD patients that were screened for inclusion, 136 were excluded due to incomplete medical data, duration of renal replacement therapy (RRT) for less than 12months, use of Mg-based-phosphate binders or other Mg-based medications or either to presence of chronic increased GI losses. Among 282 patients included in the study, 170 patients were on PPIs. Serum Mg levels were significantly lower among PPI users vs. non-users (0.94±0.2 vs. 1.03±0.2mmol/L; p<0.0001). The median duration of PPI use was 27±9.6months (range from 12 to 108) and it was not significantly associated with Mg levels (r=0.116; p=0.167). Additionally, residual renal function didn't show a significant correlation with Mg concentration (r=-0.102; p=NS) in both groups of patients. The use of PPIs was an independent and strong predictor of low Mg concentrations even in multivariate analysis (OR 3.05; 95% CI 1.2498-7.4594, p=0.01). On the other hand, the daily dose of PPIs was not associated with l...Continue Reading

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Citations

Jul 1, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Anique D Ter BraakeJeroen H F de Baaij
May 8, 2019·International Journal of Environmental Research and Public Health·Benjamin Ka Seng ThongKok-Yong Chin
Apr 26, 2019·Therapeutic Advances in Drug Safety·Megan Jaynes, Avinash B Kumar
Nov 7, 2019·Medicine·Thawin SrinuttaPaweena Susantitaphong
Jul 28, 2020·Journal of Nephrology·Geoffroy Desbuissons, Lucile Mercadal
Jul 20, 2021·Pharmacology Research & Perspectives·George LiamisHaralampos Milionis
Nov 19, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kou KitabayashiIchiei Narita

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