PMID: 11920861Mar 29, 2002Paper

Is there a relationship between Wolfram syndrome carrier status and suicide?

American Journal of Medical Genetics
Joanna CrawfordRobert D Goldney

Abstract

Wolfram syndrome (WFS) is a rare, autosomal recessive neurodegenerative disorder. An increased risk of psychiatric disorders and suicide has been reported for heterozygote carriers. In this study we investigated whether mutations in the WFS gene are associated with suicide in the general population. The gene for WFS (WFS1) has recently been mapped to chromosome 4p16.1, and its genomic structure has been characterized. We screened the entire WFS1 ORF in a panel of 100 completed suicides, 60 blood donors not known to have psychiatric illness, and 100 donors with a negative history of depression or suicidal behavior. We did not find evidence of an increased incidence of WFS carriers in the suicide panel and concluded that WFS1 carrier status is not a significant contributor to suicide in the general population. Screening of this highly polymorphic gene resulted in the detection of 33 variants, 13 of which cause amino acid changes. Seven of these changes have not been previously reported and six were unique to our suicide panel.

References

Feb 1, 1979·Psychological Medicine·D P Goldberg, V F Hillier
Jul 1, 1995·The American Journal of Psychiatry·A RoyM Sarchiapone
Dec 1, 1995·Diabetes Care·B T KinsleyR G Swift
Mar 10, 1998·Molecular Psychiatry·R G SwiftM Swift
Jul 14, 2000·American Journal of Medical Genetics·F MiddleN Craddock
Feb 24, 2001·The Australian and New Zealand Journal of Psychiatry·R D GoldneyA C McFarlane
Mar 13, 2001·Molecular Psychiatry·R TorresM H Polymeropoulos

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Citations

Jul 5, 2011·Endocrine·Georgios BoutziosEvanthia Diamanti-Kandarakis
Apr 5, 2011·Journal of Physiology and Biochemistry·Anton TerasmaaEero Vasar
Sep 10, 2005·European Journal of Human Genetics : EJHG·Lars HansenThomas Rosenberg
Apr 27, 2005·Molecular Psychiatry·M Swift, R G Swift
Dec 21, 2006·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Dan RujescuIna Giegling
Mar 31, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gil ZalsmanJ John Mann
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·Z M LarsenUNKNOWN Danish Study Group of IDDM in Childhood
Aug 27, 2010·Clinical Genetics·L RigoliC Di Bella
Sep 18, 2015·Frontiers in Molecular Neuroscience·Karin TeinAnton Terasmaa
Jul 28, 2004·Diabetes Care·Casey J A SmithRodney J Scott
Jun 5, 2003·Mental Retardation and Developmental Disabilities Research Reviews·Walter E Nance

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