PMID: 11915434Mar 28, 2002Paper

Is there a relationship between zinc and the peculiar comorbidities of Down syndrome?

Down's Syndrome, Research and Practice : the Journal of the Sarah Duffen Centre
Corrado RomanoPinella Failla

Abstract

Zinc plays a central role in the immune system and has been found to be significantly reduced in people with Down syndrome. The effectiveness of zinc supplementation in people with Down syndrome has been reported with discordant results. A comparison was made between a range of clinical and biochemical variables and zinc levels in 120 individuals with Down syndrome. Two groups of participants, one with normal zinc levels and the second with low zinc levels, were compared on the following measures: growth hormone secretion, IgA and IgG antigliadin antibodies, presence of coeliac disease, T3, T4, fT3, fT4, TSH, hypothyroidism, hyperthyroidism, CD4/CD8 ratio, total immunoglobulins G and subclasses. No significant difference was found between the two groups, except for IgG4 which was, unexpectedly, significantly decreased in the group with normal zinc levels. In conclusion, an impairment of zinc blood level in individuals with Down syndrome does not necessarily impact on the organs and systems evaluated here.

Citations

Dec 4, 2008·Biological Trace Element Research·Dilina do Nascimento MarreiroFrancisco Erasmo Oliveira
Aug 31, 2007·Acta Paediatrica·Guido CocchiLuigi Corvaglia
Dec 17, 2005·The Journal of Pediatrics·Michelle M GarrisonDimitri A Christakis
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yaddanapudi Ravindranath
Sep 14, 2018·Biological Trace Element Research·Andrey R GrabeklisAlexey A Tinkov

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