Is there a role for autotransplants in AML in first remission?

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Tara Seshadri, Armand Keating

Abstract

Over the past decade autologous hematopoietic cell transplantation has fallen out of favor as consolidation therapy for acute myeloid leukemia (AML) in first remission (CR1). This, in part, can be attributed to the results of a number of prospective trials, many of which compared outcomes of myeloablative HLA-matched sibling allotransplants with autotransplants using bone marrow-derived autografts. More recent studies, including one from the Center for International Blood and Marrow Transplant Research, explore how peripheral blood autotransplants, influence outcomes. In this brief review, a rationale for a reexamination of the use of autotransplants for de novo AML in CR1 is explored.

References

Mar 22, 2003·Blood·Jacques DelaunayUNKNOWN Bordeaux-Grenoble-Marseille-Toulouse cooperative groups
May 9, 2003·The New England Journal of Medicine·J Anthony ChildUNKNOWN Medical Research Council Adult Leukaemia Working Party
Aug 4, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R F SchlenkG Heil
Nov 13, 2007·Critical Reviews in Oncology/hematology·Felicetto FerraraFranco Leoni
May 3, 2008·The New England Journal of Medicine·Richard F SchlenkUNKNOWN German-Austrian Acute Myeloid Leukemia Study Group
Jun 21, 2008·Blood·Kumudha BalakrishnanVarsha Gandhi

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Citations

Jun 1, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Debora CapelliAttilio Olivieri
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andre S JungEdward D Ball
Aug 22, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Matthew P MuléChristopher S Hourigan

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