Is there a role for HIPEC in ovarian cancer?

Archives of Gynecology and Obstetrics
Philipp HarterChristina Fotopoulou

Abstract

Hyperthermic intraperitoneal chemotherapy (HIPEC) is promoted by some as a standard treatment for peritoneal carcinomatosis of epithelial ovarian cancer (EOC) and other tumor entities, despite lack of robust data supporting this. Publicly available evidence addressing the value of HIPEC in EOC is rather inconclusive, revealing contradictory and inconsistent results while some studies even report harm to the patients from a higher morbidity. On this ground, we cannot recommend the implementation and use of HIPEC outside of a randomized clinical trial setting.

References

Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vic J VerwaalFrans A N Zoetmulder
Apr 29, 2014·Geburtshilfe und Frauenheilkunde·P HarterUNKNOWN for the Kommission Ovar of the Arbeitsgemeinschaft Gynäkologische Onkologie
Jan 18, 2018·The New England Journal of Medicine·David R Spriggs, Oliver Zivanovic
Jan 18, 2018·The New England Journal of Medicine·Willemien J van DrielGabe S Sonke
Apr 5, 2018·The New England Journal of Medicine·Willemien J van DrielGabe S Sonke
Apr 6, 2018·The New England Journal of Medicine·Marco CeresoliLuca Ansaloni
Jun 7, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C FotopoulouA Du Bois

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Citations

Jul 18, 2020·Current Opinion in Oncology·Jan B VermorkenAlison Brand
Apr 10, 2021·Current Problems in Surgery·John H StewartKonstantinos I Votanopoulos

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