Is there a role for ischaemic conditioning in cardiac surgery?

F1000Research
Luciano Candilio, Derek J Hausenloy

Abstract

Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Coronary artery bypass graft (CABG) surgery is the revascularisation strategy of choice in patients with diabetes mellitus and complex CAD. Owing to a number of factors, including the ageing population, the increased complexity of CAD being treated, concomitant valve and aortic surgery, and multiple comorbidities, higher-risk patients are being operated on, the result of which is an increased risk of sustaining perioperative myocardial injury (PMI) and poorer clinical outcomes. As such, new treatment strategies are required to protect the heart against PMI and improve clinical outcomes following cardiac surgery. In this regard, the heart can be endogenously protected from PMI by subjecting the myocardium to one or more brief cycles of ischaemia and reperfusion, a strategy called "ischaemic conditioning". However, this requires an intervention applied directly to the heart, which may be challenging to apply in the clinical setting. In this regard, the strategy of remote ischaemic conditioning (RIC) may be more attractive, as it allows the endogenous cardioprotective strategy to be applied away from the heart to the arm or leg by simply inflating...Continue Reading

References

Jul 31, 1993·Lancet·D M YellonW B Pugsley
Mar 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B GünaydinY Karadenizli
Dec 4, 2002·Circulation·R K KharbandaR MacAllister
Apr 12, 2003·Journal of Molecular and Cellular Cardiology·Derek J Hausenloy, Derek M Yellon
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Derek J HausenloyMichael R Duchen
Jun 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Selvaraj ShanmuganathanDerek M Yellon
Sep 28, 2005·Circulation·Patrick StaatMichel Ovize
May 1, 2007·The Journal of Thoracic and Cardiovascular Surgery·Wanjun LuoRimao Huang
Jun 2, 2007·Heart Failure Reviews·Derek J Hausenloy, Derek M Yellon
Aug 8, 2007·Pharmacology & Therapeutics·Derek J Hausenloy, Derek M Yellon
Sep 11, 2007·Diabetes, Obesity & Metabolism·D J Hausenloy, D M Yellon
Dec 15, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Wanjun LuoGuoqiang Lin
May 6, 2008·Cardiovascular Research·Derek J Hausenloy, Derek M Yellon
May 23, 2008·Interactive Cardiovascular and Thoracic Surgery·Fausto BiancariMartti Lepojärvi
Sep 12, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Stewart R WalshMichael E Gaunt
Oct 16, 2008·Interactive Cardiovascular and Thoracic Surgery·Bei LiWanjun Luo
Feb 17, 2009·Cardiovascular Research·Derek J Hausenloy, Derek M Yellon
Feb 27, 2009·Basic Research in Cardiology·Derek J HausenloyDerek M Yellon
Mar 26, 2009·Journal of Molecular and Cellular Cardiology·Sandrine Lecour
Mar 28, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Vinod VenugopalDerek J Hausenloy
Jun 11, 2009·Journal of Cellular and Molecular Medicine·Vivek SivaramanDerek M Yellon
Aug 12, 2009·Cardiovascular Research·Lydia LacerdaSandrine Lecour
May 8, 2010·Basic Research in Cardiology·Shiang Y LimDerek J Hausenloy
May 25, 2010·Cardiovascular Drugs and Therapy·Derek J Hausenloy, Derek M Yellon
Aug 9, 2011·Journal of Cardiovascular Pharmacology and Therapeutics·Luciano CandilioDerek M Yellon

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Methods Mentioned

BETA
coronary artery bypass

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