Is there a role for neoadjuvant chemotherapy in the treatment of stage IV serous endometrial carcinoma?

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
E DespierreF Amant

Abstract

Serous endometrial carcinoma (SEC) is an uncommon variant of endometrial carcinoma that is notorious for its aggressive clinical course. Similar to its ovarian counterpart, it has a propensity for early intraabdominal and lymphatic spread. We present two cases of advanced SEC, who were left with no residual tumor after neoadjuvant chemotherapy. After three courses of chemotherapy, both patients underwent interval debulking surgery, resulting in no residual disease. The documentation of chemosensitivity might enable the clinician to select a subpopulation of patients with widespread SEC that might benefit from interval debulking surgery.

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Citations

Jan 1, 2007·Women's Health·Selvan PatherJonathan Carter
Sep 12, 2015·Lancet·Philippe MoriceEmile Darai
Aug 6, 2014·BioMed Research International·Lee FarrandBenjamin K Tsang
Sep 25, 2012·Gynecologic Oncology·Marcela G del CarmenJohn O Schorge
Jul 14, 2009·Gynecologic Oncology·David M BorutaAlexander B Olawaiye
Sep 1, 2007·Current Opinion in Oncology·Frederic AmantIgnace Vergote
Feb 21, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Serina DaiTomer Feigenberg
Aug 7, 2012·The International Journal of Biological Markers·Thijs RoelofsenLeon F A G Massuger
Dec 21, 2010·Expert Review of Anticancer Therapy·Thijs RoelofsenLeon F Massuger
Mar 2, 2021·Gynecologic Oncology Reports·L PhilpA Goodman

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