Is there a role for periurethral collagen injection in the management of urodynamically proven mixed urinary incontinence?

Urology
Christina I Poon, Philippe E Zimmern

Abstract

To investigate the effectiveness of periurethral collagen injection (PCI) in patients presenting with symptoms of mixed urinary incontinence (MUI) and urodynamically demonstrated sphincter deficiency and detrusor overactivity. A retrospective review was performed on all patients undergoing PCI from February 1999 to February 2003, during which those with MUI were treated with PCI as first-line therapy. The inclusion criteria were MUI symptoms, detrusor overactivity on urodynamic study, stress urinary incontinence due to sphincter deficiency (determined from physical examination, stress test, urodynamic study with Valsalva leak point pressure, and cystography findings, without urethral hypermobility). The primary outcome measures were the Urogenital Distress Inventory (UDI), Incontinence Impact Questionnaire, and quality-of-life score and the need for anticholinergic medications or additional surgery. Comparisons were performed using the Wilcoxon signed ranks test and paired t test. Of the 56 patients who underwent PCI, 43 presented with symptoms of MUI, and 16 of these (29%) had both detrusor overactivity and stress urinary incontinence on urodynamic study. The mean follow-up after PCI (without additional PCI) was 18 months (ran...Continue Reading

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Sep 9, 2004·Current Opinion in Obstetrics & Gynecology·Christina I Poon, Philippe E Zimmern

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Citations

Aug 28, 2009·Current Urology Reports·Ahmed F KotbJacques Corcos
Aug 11, 2012·The Urologic Clinics of North America·W Stuart Reynolds, Roger R Dmochowski

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