Is there a role for PET/CT parameters to differentiate thyroid cartilage invasion from penetration?

European Journal of Radiology
Ayse Tuba Karagulle KendiPatricia A Hudgins

Abstract

Assessment of thyroid cartilage invasion (tumor extension through inner cortex) and thyroid cartilage penetration (tumor involving both the inner and outer cortices of thyroid cartilage) may be challenging with CT (Computed Tomography) and MR imaging (Magnetic Resonance Imaging). Positron Emission Tomography/Computed Tomography (PET/CT) is a non invasive imaging modality that provides both anatomic and metabolic information. Quantitative data obtained from PET/CT, also known as PET/CT parameters, include maximum, mean or peak standardized uptake values (SUVmax, SUVmean, SUVpeak), metabolic tumor volume (MTV), total lesion glycolysis (TLG), standardized added metabolic activity (SAM) and normalized standardized added metabolic activity (NSAM). Our aim was to examine if FDG PET/CT parameters could differentiate thyroid cartilage invasion from penetration. 50 patients who underwent PET/CT before laryngectomy for squamous cell carcinoma of the larynx, had SUVmax, SUVmean, SUVpeak, TLG, MTV, SAM and NSAM calculated on a dedicated workstation. Univariate and multivariate analysis was performed. ROC analysis was used to determine the ability of PET/CT parameters to predict pathologically proven thyroid cartilage invasion or penetratio...Continue Reading

References

May 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marine SoretIrène Buvat
Apr 11, 2012·Head & Neck·Svetlana S KatsJonathan J Beitler
Sep 25, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G C ParkS Y Kim
Aug 26, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·In Sun RyuKyung-Ja Cho
Jan 22, 2015·Clinical Nuclear Medicine·Ayse Tuba Karagulle KendiDavid M Schuster

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Citations

Oct 27, 2018·The Annals of Otology, Rhinology, and Laryngology·Luca Giovanni LocatelloGiuditta Mannelli

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