Is there a role for positron emission tomography with 18F-fluorodeoxyglucose in the initial staging of nodal negative oral and oropharyngeal squamous cell carcinoma

Head & Neck
S J StoeckliStephan Schmid

Abstract

The aim of our study was to assess the value of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) for the staging of clinically nodal negative necks in oral and oropharyngeal squamous cell carcinoma (SCC) using sentinel lymph node (SLN) biopsy and elective neck dissection (END) as "gold standard" for comparison. Twelve patients (10 men, 2 women) with oral or oropharyngeal squamous cell carcinoma and no evidence of lymph node metastasis in the physical and radiologic examinations were eligible. At least 24 hours before surgery PET with FDG were performed. The SLN was localized by preoperative lymphoscintigraphy with 99m-Tc-Nanocoll and intraoperative use of a hand-held gamma-probe and selectively excised. All patients then underwent END. SLN and END revealed occult metastasis in 5 of 12 cases. SLN biopsy was accurately feasible in all 12 patients and diagnosed all 5 cases of occult metastasis (sensitivity and specificity of 100%). PET suggested two patients having occult metastasis, of which one turned out to be false positive (sensitivity 25%, specificity 88%). The mean size of the micrometastasis was 1.4 mm (range, 1.2-1.5 mm). PET with FDG turned out to have a poor sensitivity and specificity in revealing o...Continue Reading

References

Jan 1, 1988·Head & Neck Surgery·R M ByersA J Ballantyne
Dec 1, 1996·Hematology/oncology Clinics of North America·S K Ballas, N Mohandas
Dec 1, 1996·Archives of Otolaryngology--head & Neck Surgery·L Barzan, R Talamini
Feb 1, 1997·Archives of Otolaryngology--head & Neck Surgery·R M MerrittE S Porubsky
Feb 24, 1998·The Laryngoscope·L L MyersD Lamonica
Sep 19, 2000·Virchows Archiv : an International Journal of Pathology·H HamakawaK Sogawa
Sep 14, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S J StoeckliS Schmid

❮ Previous
Next ❯

Citations

Jul 6, 2004·Annals of Nuclear Medicine·Kazuaki ChikamatsuNobuhiko Furuya
Feb 12, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Klaus StrobelThomas F Hany
Feb 16, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Eric M GendenAlessandra Rinaldo
Sep 20, 2005·Odontology·Gary L Ross, Taimur Shoaib
Jan 30, 2007·Clinical & Experimental Metastasis·Kathrin RupertusMartin K Schilling
Jan 15, 2003·Current Treatment Options in Oncology·Terry A DayRobert K Stuart
Feb 19, 2005·Current Oncology Reports·David I KutlerDennis H Kraus
Oct 24, 2007·La Presse médicale·Jean-Noël TalbotJean-Didier Grange
Aug 4, 2004·Oral Oncology·Pontus K E BörjessonGuus A M S van Dongen
Jul 2, 2003·Journal of the American College of Surgeons·David W Kim, Dean M Toriumi
Mar 6, 2003·Oral Oncology·Eric M GendenCrispian Scully
Apr 5, 2003·Oral Oncology·Karen T PitmanAlessandra Rinaldo
Jan 13, 2006·Nuclear Medicine Communications·Heok K CheowMichael J O'Doherty
Mar 23, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·David I KutlerDennis H Kraus
Oct 11, 2008·American Journal of Clinical Oncology·Dwight E HeronRyan P Smith
Apr 2, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Moni Abraham Kuriakose, Nirav P Trivedi
Dec 29, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery·Sandro J Stoeckli, Martina A Broglie
Dec 7, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·P S Richards, T E Peacock
Nov 18, 2011·Radiation Oncology·Harald EssigNils-Claudius Gellrich
Jul 20, 2010·Head & Neck Oncology·Gregory J KubicekMitchell Machtay
Jun 16, 2004·Annals of Surgical Oncology·Gary L RossFranco Alberti
Jun 25, 2008·Annals of Surgical Oncology·Masayuki TomifujiKaoru Ogawa
Aug 6, 2013·European Journal of Internal Medicine·Luca Tagliabue, Angelo Del Sole
Jul 19, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Wouter V VogelWim J G Oyen
Mar 18, 2008·The British Journal of Radiology·A D KingA T C Chan
May 26, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Maky A HafidhConrad V Timon
Jan 4, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Bulent CetinMustafa Benekli
Jul 14, 2010·Journal of Cancer Research and Therapeutics·Vishal U S RaoB Karthikeyan
Dec 4, 2012·Neuroimaging Clinics of North America·Amit M Saindane
Apr 13, 2010·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Matthias FeichtingerHans Kärcher
Oct 23, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Yongnan PiaoHitoshi Shibuya
Jul 1, 2008·PET Clinics·Laurie A LoevnerIgor Mikityansky
Mar 17, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dominic A X SchinaglJohannes H A M Kaanders
Oct 1, 2007·PET Clinics·Gaurang V ShahSuresh K Mukherji
Nov 18, 2008·Hematology/oncology Clinics of North America·Sandro V PorcedduRodney J Hicks
Jan 22, 2008·Revue de stomatologie et de chirurgie maxillo-faciale·A S RicardC Majoufre-Lefebvre
Feb 12, 2008·Otolaryngologic Clinics of North America·Vikas AgarwalJonas T Johnson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.