Is there a role for positron emission tomography imaging in the early evaluation of prostate cancer relapse?

Prostate Cancer and Prostatic Diseases
C GrecoO Tamburrini

Abstract

The patient population with a rising prostate specific antigen (PSA) post-therapy with no evidence of disease on standard imaging studies currently represents the second largest group of prostate cancer patients. Little information is still available regarding the specificity and sensitivity of positron emission tomography (PET) tracers in the assessment of early biochemical recurrence. Ideally, PET imaging would allow one to accurately discriminate between local vs nodal vs distant relapse, thus enabling appropriate selection of patients for salvage local therapy. The vast majority of studies show a relatively poor yield of positive scans with PSA values < 4 ng ml(-1). So far, no tracer has been shown to be able to detect local recurrence within the clinically useful 1 ng ml(-1) PSA threshold, clearly limiting the use of PET imaging in the post-surgical setting. Preliminary evidence, however, suggests that 11C-choline PET may be useful in selecting out patients with early biochemical relapse (PSA < 2 ng ml(-1)) who have pelvic nodal oligometastasis potentially amenable to local treatment. The role of PET imaging in prostate cancer is gradually evolving but still remains within the experimental realm. Well-conducted studies com...Continue Reading

References

May 11, 1999·JAMA : the Journal of the American Medical Association·C R PoundP C Walsh
Jul 1, 1999·International Journal of Radiation Oncology, Biology, Physics·B PickettM Roach
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·C C LingJ A Koutcher
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M W KattanS A Leibel
Nov 18, 2000·Clinical Nuclear Medicine·M CharronD W Townsend
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A K LeventisK M Slawin
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Markus GraefenMichael W Kattan
Sep 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Jörg KotzerkeSven N Reske
Nov 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony V D'AmicoDelray Schultz
Feb 18, 2003·European Journal of Nuclear Medicine and Molecular Imaging·E FrickeA R Boerner
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cherry T ThomasRichard L Wahl
Jun 20, 2003·The New England Journal of Medicine·Mukesh G HarisinghaniRalph Weissleder
Sep 10, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Heiko SchöderHenry W D Yeung
Oct 23, 2003·Seminars in Oncology·Hedvig HricakHoward I Scher
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W KattanSteven A Leibel
Jan 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard I ScherHoward R Soule
Mar 18, 2004·JAMA : the Journal of the American Medical Association·Andrew J StephensonKevin M Slawin
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Fernando J BiancoJames A Eastham
Jul 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heiko SchöderSteven M Larson
Jul 30, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Takako YamaguchiTomio Inoue
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew K Lee, Anthony V D'Amico
Nov 30, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Martin HeinischWerner Langsteger
Feb 14, 2006·Nature Clinical Practice. Urology·John F Ward, Judd W Moul
Mar 28, 2006·Seminars in Radiation Oncology·Brian D KavanaghRobert D Timmerman
May 10, 2006·International Journal of Radiation Oncology, Biology, Physics·Anthony V D'AmicoMing-Hui Chen
Jul 13, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Susanne AlbrechtRaymond Miralbell
Jul 25, 2006·Hematology/oncology Clinics of North America·Judd W Moul, John F Ward
Jul 26, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Marino CimitanMauro G Trovò
Dec 13, 2006·Radiologic Clinics of North America·Oguz Akin, Hedvig Hricak

❮ Previous
Next ❯

Citations

Jul 19, 2013·International Journal of Molecular Sciences·Sara AlcornPhuoc T Tran
Jul 12, 2008·Acta Oncologica·Carlo Greco, C Clifton Ling
Jan 27, 2010·Cancer Treatment Reviews·Christian Boukaram, Jean-Michel Hannoun-Levi
Apr 22, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Zsolt SzaboMartin G Pomper
Jun 26, 2015·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·José López TorrecillaCarmen González San Segundo
Feb 21, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Donika PlykuRobert F Hobbs
Dec 1, 2010·Journal of Conservative Dentistry : JCD·Udayakumar Jayasimha Raj, Sumitha Mylswamy
Aug 24, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Damaris KukukBernd J Pichler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Seiichi YanoRui-Ping Dong
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Samuel SamnickCarl-Martin Kirsch
© 2021 Meta ULC. All rights reserved