Is there a role for probiotics in the prevention of preterm birth?

Frontiers in Immunology
Siwen YangAlan Bocking

Abstract

Preterm birth (PTB) continues to be a global health challenge. An over-production of inflammatory cytokines and chemokines, as well as an altered maternal vaginal microbiome has been implicated in the pathogenesis of inflammation/infection-associated PTB. Lactobacillus represents the dominant species in the vagina of most healthy pregnant women. The depletion of Lactobacillus in women with bacterial vaginosis (BV) has been associated with an increased risk of PTB. It remains unknown at what point an aberrant vaginal microbiome composition specifically induces the cascade leading to PTB. The ability of oral or vaginal lactobacilli probiotics to reduce BV occurrence and/or dampen inflammation is being considered as a means to prevent PTB. Certain anti-inflammatory properties of lactobacilli suggest potential mechanisms. To date, clinical studies have not been powered with sufficiently high rates of PTB, but overall, there is merit in examining this promising area of clinical science.

References

Jan 1, 1989·Prostaglandins·R RomeroM D Mitchell
May 16, 2000·Obstetrics and Gynecology·A Y El-BastawissiJ N Krieger
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Jun 28, 2000·American Journal of Obstetrics and Gynecology·M G GravettD A Eschenbach
Aug 19, 2000·Acta Obstetricia Et Gynecologica Scandinavica·G von MinckwitzM Kaufmann
Feb 13, 2001·Obstetrics and Gynecology·J HittiD A Eschenbach
May 23, 2001·Infectious Diseases in Obstetrics and Gynecology·J SmayevskyH Bianchini
Dec 26, 2001·FEMS Immunology and Medical Microbiology·G ReidA W Bruce
May 31, 2002·Journal of Clinical Microbiology·Sabina CauciSecondo Guaschino
Jun 18, 2002·American Journal of Obstetrics and Gynecology·Tinnakorn ChaiworapongsaRicardo Gomez
Jul 2, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·John R G ChallisJohn P Newnham
Oct 17, 2002·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·P PacoraR Romero
Jul 5, 2003·Placenta·J A KeelanM D Mitchell
Jul 12, 2003·American Journal of Reproductive Immunology : AJRI·M MakhseedM M K Al-Azemi
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Gregor Reid, Alan Bocking
Jun 29, 2004·Journal of Clinical Gastroenterology·L MorelliP Cognein
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Hans VerstraelenMario Vaneechoutte
Apr 9, 2005·Journal of Clinical Gastroenterology·Koji NishijimaFumikazu Kotsuji
May 17, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jacek R Wilczyński
Jun 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Corinne GrangetteAnnick Mercenier
Oct 7, 2005·Archives of Gynecology and Obstetrics·Miranda Farage, Howard Maibach
Nov 4, 2005·The New England Journal of Medicine·David N FredricksJeanne M Marrazzo
Dec 21, 2005·American Journal of Reproductive Immunology : AJRI·Nazeeh HannaSurendra Sharma
Jan 27, 2007·The Cochrane Database of Systematic Reviews·H M McDonaldA Gordon
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M OthmanZ Alfirevic
Feb 22, 2007·The Journal of Nutrition·Marcel Roberfroid
Apr 20, 2007·Journal of Reproductive Immunology·Ida VogelWilliam W Andrews
Jun 5, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Harro M TimmermanGer T Rijkers
Jul 27, 2007·Journal of Clinical Microbiology·Tell Jakobsson, Urban Forsum
Sep 1, 2007·Clinical Obstetrics and Gynecology·Francesca GotschSonia S Hassan

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Citations

Mar 10, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·M ChamperJ D Wright
Sep 29, 2017·Biological Research for Nursing·Seon-Yoon ChungMary Regan
May 24, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·N TabatabaeiW D Fraser
Feb 29, 2020·Journal of Women's Health·Jessica S WellsGlenna Brewster
Jul 25, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Anderson Santos de FreitasLuiz Fernando Wurdig Roesch
Oct 18, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Xiaochun YiJianping Zhang
Jan 25, 2019·The Journal of Perinatal & Neonatal Nursing·Alexis B DunnSharon Leslie
Apr 4, 2021·Biomolecules·Amrit Pal KaurDinesh Kumar
Aug 16, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Chen ChenHuijue Jia

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Methods Mentioned

BETA
PCR

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