Is there a role for treatment of asthma with omalizumab?

Archives of Disease in Childhood
H Milgrom

Abstract

The allergic response is distinct from other immune reactions in its reliance on IgE, its high affinity receptor, Fc epsilon RI, and the primary effector cell--the tissue mast cell. Positive skin tests or raised concentrations of specific immunoglobulin E (IgE) in the serum define IgE sensitisation or "atopy". IgE participates both in immediate hypersensitivity response and in the induction of chronic allergic inflammation. It enhances allergen capture and Th2 cell activation, and may trigger other immunoregulatory pathways. Considerable effort in therapeutic research has focused on interference with IgE function because of its position high in the allergic cascade. Therapy with anti-IgE is one such approach that shows much promise.

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Citations

Oct 12, 2005·Current Allergy and Asthma Reports·Theresa A O'Lonergan, Henry Milgrom
Jul 4, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Bobby Q Lanier
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Apr 7, 2015·Progress in Biophysics and Molecular Biology·Kimberly R ShorterPaul B Vrana
Dec 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Liu YangZhiping Wang
Sep 19, 2019·International Journal of Pediatric Otorhinolaryngology·Nuray Bayar MulukCemal Cingi

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