Is there a role for unstimulated thyroglobulin velocity in predicting recurrence in papillary thyroid carcinoma patients with detectable thyroglobulin after radioiodine ablation?

Annals of Surgical Oncology
Hilda WongBrian Hung-Hin Lang

Abstract

In the follow-up of papillary thyroid cancer (PTC) patients treated with curative thyroidectomy and radioiodine ablation, raised thyroglobulin (Tg) predicts recurrence with reasonable sensitivity and specificity. However, a proportion of patients present with raised Tg level but no other clinical evidence of disease. Only limited data on Tg kinetics have been reported to date. Here we aim to evaluate the prognostic and predictive significance of nonstimulated serum Tg velocity (TgV). Consecutive PTC patients treated with curative thyroidectomy and radioiodine ablation between 2003 and 2010 were analyzed. Patients with at least one detectable Tg measurement (>0.2 ng/mL) were included. TgV was defined as the annualized rate of Tg change. Logistic regression analyses were performed to evaluate the role of TgV in the prediction of disease recurrence. The optimal TgV cutoff was assigned by receiver-operating characteristic curve analysis. Overall survival of patients above versus below the TgV cutoff were determined by the Kaplan-Meier method and compared. Of a total of 501 patients, 87 had at least one Tg value >0.2 ng/mL; in these latter patients, 29 (33.3%) developed recurrence. TgV was an independent predictor of the recurrence....Continue Reading

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Citations

Jan 10, 2014·Endocrine-related Cancer·Brian Hung-Hin LangYeo-Kyu Youn
Nov 29, 2013·Thyroid : Official Journal of the American Thyroid Association·Pedro Weslley Rosário, Maria Regina Calsolari
Oct 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Pedro Weslley RosarioMaria Regina Calsolari
Jun 4, 2014·Endocrinology and Metabolism Clinics of North America·Denise P Momesso, R Michael Tuttle
Oct 31, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Luca GiovanellaPenelope M Clark
Oct 18, 2016·Thyroid : Official Journal of the American Thyroid Association·Ronja Maria RössingRainer Görges
Feb 26, 2016·Archives of Endocrinology and Metabolism·Pedro Weslley Rosario, Gabriela Franco Mourão
Dec 4, 2014·Arquivos brasileiros de endocrinologia e metabologia·Pedro Weslley Rosario, Maria Regina Calsolari

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Methods Mentioned

BETA
dissection
X-ray
enzyme-linked immunosorbent assay

Software Mentioned

SPSS Statistics

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