Is there a serotonin-induced hypertensive coronary chemoreflex in the nonhuman primate?

Circulation Research
K G Cornish, I H Zucker

Abstract

The purpose of this study was to investigate the nature of the serotonin-induced coronary chemoreflex in the conscious monkey. Ten chronically prepared and four acute monkeys were used in this study. Five chronically prepared animals had catheters in the left atrium, ascending aorta, descending aorta, and, bilaterally, in the common carotid arteries. In addition, Silastic catheters were placed next to both vagi to permit vagal block with 2% lidocaine. Serotonin was injected (12-200 micrograms/kg) into the left atrium, ascending aorta, descending aorta, or, bilaterally, into the carotid arteries while blood pressure, heart rate, and respiratory movements were recorded. Injections of serotonin were associated with hypertension and bradycardia followed by tachycardia, all of which were preceded by a cough response. Atropine blocked the bradycardia, whereas atropine and phentolamine eliminated the cardiovascular components of the reflex. Vagal blockade eliminated the bradycardia but otherwise did not alter the response to left atrial serotonin. Three monkeys were prepared with aortic and left atrial catheters. Subsequently, they were subjected to sinoaortic deafferentation. Serotonin injected into these animals did not alter blood ...Continue Reading

References

Oct 22, 1979·The American Journal of Cardiology·T N JamesF Urthaler
Aug 1, 1975·Circulation·T N JamesF Urthaler
Apr 1, 1971·Journal of Applied Physiology·R W EcksteinN Oya
Mar 1, 1980·Cardiovascular Research·F UrthalerG R Hageman

❮ Previous
Next ❯

Citations

Nov 5, 1999·The New England Journal of Medicine·D R Abernethy, J B Schwartz
Feb 1, 1993·Clinical and Experimental Pharmacology & Physiology·K HayashiM Watanabe
Feb 1, 1991·Clinical and Experimental Pharmacology & Physiology·J Ludbrook, R G Evans

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.