Is there a survival benefit from adjuvant chemotherapy for patients with liver oligometastases from colorectal cancer after curative resection?

Cancer Communications
Zhi-Zhong PanDe-Sen Wan

Abstract

Although colorectal oligometastases to the liver can potentially be cured with aggressive local ablation, the efficacy of adjuvant chemotherapy (ACT) for such metastasis remains unclear. The present study explored the effects of ACT on patients with colorectal liver oligometastases (CLO) after curative resections and aimed to identify patients who could benefit from ACT. We retrospectively analyzed 264 eligible patients with CLO who underwent curative resection between September 1999 and June 2015. Recurrence-free survival (RFS) and overall survival (OS) were analyzed using the Kaplan-Meier method and log-rank test; prognostic factors were a by Cox regression modeling. Among 264 patients, 200 (75.8%) patients received ACT and 64 (24.2%) did not receive ACT. These two groups did not significantly differ in clinicopathologic characteristics, and had comparable 3-year OS and RFS rates (RFS: 42.1% vs. 45.7%, P = 0.588; OS: 69.7% vs. 62.7%, P = 0.446) over a median follow-up duration of 35.5 months, irrespective of preoperative chemotherapy. ACT markedly improved 3-year OS in high-risk patients with Memorial Sloan-Kettering Cancer Center clinical risk scores (MSKCC-CRS) of 3-5 (68.2% vs. 33.8%, P = 0.015), but presented no additiona...Continue Reading

References

Apr 19, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfred I NeugutDawn L Hershman
Aug 23, 2006·Future Oncology·Derek A O'Reilly, Graeme J Poston
Mar 14, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H Z MalikK R Prasad
Sep 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emmanuel MitryPhilippe Rougier
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thierry AndréAimery de Gramont
Nov 3, 2010·Annals of Surgical Oncology·Michael D'AngelicaWilliam R Jarnagin
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel G HallerHans-Joachim Schmoll
Feb 9, 2012·Annals of Surgery·Halfdan SorbyeUNKNOWN Fédération Francophone de Cancérologie Digestive (FFCD)
Apr 25, 2012·Annals of Surgical Oncology·Zhu DexiangXu Jianmin
Jul 16, 2014·International Journal of Colorectal Disease·Hung-Hsin LinShih-Ching Chang
Sep 2, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans-Joachim SchmollDaniel G Haller
Jul 7, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemD Arnold
Mar 3, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Akira OokiKensei Yamaguchi

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Citations

Mar 25, 2020·The Cancer Journal·Navid Hafez, Scott Gettinger
Mar 5, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yunzhu DaiRuhai Zou

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