Is there a threshold that triggers cortical arousals in obstructive sleep apnea

Sleep
Yanru LiAtul Malhotra

Abstract

To determine whether there is a consistent epiglottic pressure value that predicts respiratory arousal from sleep. Thirty-one patients with obstructive sleep apnea underwent overnight polysomnography while instrumented with an epiglottic catheter to measure airway pressures. Nadir epiglottic pressures during respiration events (obstructive apneas/hypopneas) terminated with or without arousals were compared. The events were selected by two methods, (1) 20 events with/without arousals were randomly selected, and (2) Events were sampled in pairs (one terminated with arousal and one without arousal) to minimize the effect of sleep duration/stage on the measurement. A total of 1,317 respiratory events were analyzed. There was substantial variability in nadir epiglottic pressure within an individual and among different individuals. The average pressure of 20 randomly selected events with arousals was (-21.2 ± 11.2, ranged -6.68 to -63.34 cm H2O). The nadir epiglottic pressure during respiratory events in NREM stage 2 sleep terminated with arousals was more negative compared with those terminated without arousals using both sampling methods (-23.5 vs. -18.5 cm H2O, p = 0.007 and -20.3 vs. -16.3 cm H2O, p < 0.001). There were very diff...Continue Reading

Associated Clinical Trials

Oct 15, 2014·Robert L. OwensRobert L. Owens

References

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Jan 13, 2018·American Journal of Respiratory and Critical Care Medicine·Scott A SandsAndrew Wellman

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Citations

Jul 2, 2020·Nature and Science of Sleep·Islay PittawayAmy S Jordan
Sep 13, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Monique Suarez-GironJosep M Montserrat

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