Is There an Additional Value in Detecting Anticardiolipin and Anti-β2 glycoprotein I IgA Antibodies in the Antiphospholipid Syndrome?

Thrombosis and Haemostasis
Walid ChayouaKatrien M J Devreese

Abstract

Anticardiolipin (aCL) and anti-β2 glycoprotein I (aβ2GPI) immunoglobulin A (IgA) antiphospholipid antibodies (aPL) have shown to associate with thrombosis and pregnancy morbidity. However, inclusion of IgA aPL in the classification criteria of the antiphospholipid syndrome (APS) has been debated. We investigated the value of aCL and aβ2GPI IgA aPL in the detection of thrombosis and pregnancy morbidity in addition to the current aPL panel for APS. We included 1,068 patients from eight European medical centers: 259 thrombotic APS patients, 122 obstetric APS patients, 204 non-APS thrombosis patients, 33 non-APS obstetric patients, 60 APS patients with unspecified clinical manifestations, 196 patients with autoimmune diseases, and 194 controls. aCL and aβ2GPI IgG/M/A were detected with four commercial assays and lupus anticoagulant was determined by the local center. Positivity for IgA aPL was found in 17 to 26% of the patients with clinical manifestations of APS and in 6 to 13% of the control population. Both aCL and aβ2GPI IgA were significantly associated with thrombosis and pregnancy morbidity. Isolated IgA positivity was rare in patients with clinical manifestations of APS (0.3-5%) and not associated with thrombosis and/or pre...Continue Reading

References

May 22, 2003·Annals of the Rheumatic Diseases·S Carmo-PereiraG R V Hughes
Jul 25, 2009·Journal of Thrombosis and Haemostasis : JTH·V PengoUNKNOWN Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the Interna
Aug 29, 2013·Arthritis and Rheumatism·Vijaya MurthySilvia S Pierangeli
Mar 5, 2014·Journal of Thrombosis and Haemostasis : JTH·K M J DevreeseUNKNOWN Subcommittee on Lupus Anticoagulant/Phospholipid/Dependent Antibodies
Apr 18, 2014·Journal of Immunology Research·Raquel Ruiz-GarcíaAntonio Serrano
Apr 23, 2014·International Journal of Laboratory Hematology·K M J Devreese
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Mar 14, 2018·Journal of Thrombosis and Haemostasis : JTH·K M J DevreeseUNKNOWN Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies
Jul 12, 2019·Research and Practice in Thrombosis and Haemostasis·Laura VanoverscheldeKatrien M J Devreese

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Citations

Jan 30, 2021·Current Rheumatology Reports·Silvia RosinaRolando Cimaz
Mar 9, 2021·Expert Review of Clinical Immunology·Georges El HasbaniImad Uthman
Dec 1, 2020·Arthritis Care & Research·Medha BarbhaiyaUNKNOWN New APS Classification Criteria Collaborators

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