Is there an alternative to systemic anticoagulation, as related to interventional biomedical devices?

Expert Review of Medical Devices
Gemma ConnAlexander M Seifalian

Abstract

To reduce the toxic effects, related clinical problems and complications such as bleeding disorders associated with systemic anticoagulation, it has been hypothesized that by coating the surfaces of medical devices, such as stents, bypass grafts, extracorporeal circuits, guide wires and catheters, there will be a significant reduction in the requirement for systemic anticoagulation or, ideally, it will no longer be necessary. However, current coating processes, even covalent ones, still result in leaching followed by reduced functionality. Alternative anticoagulants and related antiplatelet agents have been used for improvement in terms of reduced restenosis, intimal hyperphasia and device failure. This review focuses on existing heparinization processes, their application in clinical devices and the updated list of alternatives to heparinization in order to obtain a broad overview, it then highlights, in particular, the future possibilities of using heparin and related moieties to tissue engineer scaffolds.

References

Mar 19, 1987·The New England Journal of Medicine·U SigwartL Kappenberger
Jan 1, 1983·Biomaterials, Medical Devices, and Artificial Organs·O LarmP Olsson
Nov 1, 1995·Journal of the American College of Cardiology·T TomaruY Uchida
Jan 1, 1995·Fundamental & Clinical Pharmacology·L J FeldmanP G Steg
Jun 1, 1995·The American Journal of Medicine·J R OsterL M Fishman
Apr 1, 1993·The Annals of Thoracic Surgery·Y J GuC R Wildevuur
Jan 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·R C GormanL H Edmunds
Feb 1, 1996·The Journal of Surgical Research·C GosselinH P Greisler
Jan 1, 1996·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A SáenzI Gallo
Jan 1, 1996·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·E OvrumR Oystese
Aug 1, 1996·Artificial Organs·H HorimotoS Sasaki
Nov 1, 1996·Journal of Vascular and Interventional Radiology : JVIR·R C SheleyS F Quinn
Feb 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·E FosseB Mohr
Jul 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·H te VelthuisD Y Loisance
Aug 26, 1998·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·R BlezerT Lindhout
Oct 7, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A BaderA Haverich
Mar 30, 1999·The Journal of Thoracic and Cardiovascular Surgery·V VidemJ L Svennevig
Oct 12, 1999·Circulation·M J Quinn, D J Fitzgerald
Nov 11, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·H P Wendel, G Ziemer
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M J WissinkJ Feijen

❮ Previous
Next ❯

Citations

Nov 26, 2010·Journal of Biomaterials Science. Polymer Edition·Ying Jun DuAnthony K C Chan
Oct 13, 2014·Nature Biotechnology·Daniel C LeslieDonald E Ingber
May 4, 2011·Journal of Biomedical Materials Research. Part a·Tahmer SharkawiMichel Vert
Mar 31, 2011·Biotechnology and Applied Biochemistry·Mo BaguneidAlexander M Seifalian
Mar 30, 2016·Experimental Biology and Medicine·Irini SotiriCaitlin Howell
Oct 15, 2011·Biotechnology and Applied Biochemistry·Atefeh SoloukAlexander M Seifalian
Apr 22, 2016·Annals of Biomedical Engineering·David L BarkLakshmi P Dasi
Jun 18, 2014·Journal of Biomaterials Applications·Terry C MajorRobert H Bartlett
Mar 9, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fanjun ZhangYunbing Wang
Apr 27, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tiffany R BellomoTerry C Major
Jan 21, 2017·Analytical Chemistry·Robert J SotoMark H Schoenfisch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.