Is there an association between angiotensin converting enzyme (ACE) genotypes and abdominal aortic aneurysm?

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
B ObukofeM J Bown

Abstract

There is strong evidence of a genetic predisposition to abdominal aortic aneurysm (AAA), however the genes involved remain largely elusive. Recently, two large studies have suggested an association between the angiotensin converting enzyme gene and AAA. This study aimed to investigate the possible association between the ACE insertion/deletion polymorphism and abdominal aortic aneurysm (AAA) in order to replicate the findings of other authors. A case-control study was performed including 1155 patients with aneurysms and 996 screened control subjects. DNA was extracted from whole blood and genotypes determined in 1155 AAAs and 996 controls using a two stage polymerase chain reaction (PCR) technique. The groups were reasonably matched in terms of risk factors for AAA. No association was found between the ACE gene insertion/deletion polymorphism and AAA in this study. This study cannot support the findings of previous authors and provides evidence against a link between the ACE gene insertion/deletion polymorphism and AAA.

References

May 16, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R PolaP Pola
Feb 8, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C FatiniR Abbate
Dec 22, 2006·Annals of the New York Academy of Sciences·Alan DaughertyLisa A Cassis
Feb 6, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R M SandfordR D Sayers
Oct 1, 2008·Circulation. Cardiovascular Genetics·Matthew J BownRobert D Sayers

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Citations

Oct 16, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D T BradleyA E Hughes
Dec 15, 2010·Annals of Vascular Surgery·Irene HinterseherHelena Kuivaniemi
Aug 1, 2014·Interactive Cardiovascular and Thoracic Surgery·Le-Gang HuangHai-Qing Wang
May 17, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L U LjungbergT Länne
Oct 18, 2016·Genetic Testing and Molecular Biomarkers·Andrea Crkvenac GregorekSanja Dabelic
Apr 17, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Gwan Gyu SongYoung Ho Lee
Aug 27, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yan SongZifan Wang

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