Is there an association between multiple myeloma and prostate cancer?

Medical Hypotheses
Johnny KaoSrinivasan Vijayakumar

Abstract

In a series of 700 consecutive patients with prostate cancer, four patients were noted to have a history of multiple myeloma. An association between prostate cancer and multiple myeloma had not been previously described. An exploratory investigation of the biological basis of these two malignancies was undertaken to determine a possible mechanism for this association. A review of the genetic, molecular and chemical basis of prostate cancer and multiple myeloma development and progression is presented. A model suggesting the possible impact of immunosuppression from multiple myeloma and chemokines released by circulating myeloma cells including IGF-1, IL6, SDF1 and VEGF on the progression of prostate cancer to detectable stages is presented.

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Citations

Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Tushar SehgalS C Sharma
Jan 1, 2014·Clinical Lymphoma, Myeloma & Leukemia·Reinhold MunkerTeresa G Hayes
Aug 16, 2011·Annals of Diagnostic Pathology·Mirna SučićKristina Potočki
Jul 14, 2018·Indian Journal of Pathology & Microbiology·Yelda VyasA Kalpana Bothale
Oct 22, 2011·The Korean journal of laboratory medicine·Nae Yu KimJung-Ae Lee
Oct 26, 2018·Journal of Medical Case Reports·Samik PramanikSalil K Pal
Feb 8, 2020·Indian Journal of Pathology & Microbiology·Jasmita DassJyoti Kotwal
May 16, 2018·Frontiers in Oncology·Diego Andres Adrianzen HerreraBenjamin A Gartrell

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