Is There an Association or Not?-Investigating the Association of Depressiveness, Physical Activity, Body Composition and Sleep With Mediators of Inflammation

Frontiers in Psychiatry
Frank M SchmidtChristian Sander

Abstract

Cytokines are mediators of inflammation that contribute to a low-grade inflammation in different disorders like major depression and obesity. It still remains unclear which psychological and medical factors interact with cytokine regulation. In the current investigation, the association between levels of pro-and anti-inflammatory cytokines and anthropometrics, mood state (depressiveness), physical activity and sleep were investigated in a sample of community-dwelled adults. Forty-nine subjects met the inclusion criteria for analyses and were assessed at two time-points (baseline (T1) and follow-up (T2), average T1-T2-interval = 215 days). Serum cytokine measures included the pro-inflammatory cytokines interleukin (IL)-2, IL-12, IFN-γ and TNF-α, the anti-inflammatory cytokines IL-4, IL-5, IL-10 and IL-13 and the granulocyte-macrophage colony-stimulating factor (GM-CSF); anthropometrics were assessed via physical examination, depressiveness was assessed via Beck Depression Inventory (BDI)2, parameters of physical activity (steps, METs) and sleep (night/total sleep duration) were measured via a 1-week actigraphy. Correlation analyses showed low-to moderate significant relationships between the majority of cytokines and the BDI2 at...Continue Reading

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Citations

Apr 4, 2021·Journal of Personalized Medicine·Olivia PatsalosHubertus Himmerich
May 18, 2021·Frontiers in Neuroscience·Ezio CarboniAntonello Novelli
Jul 30, 2021·Neuroscience and Biobehavioral Reviews·Minerva Ortiz-ValladaresNorma Angélica Moy-López

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