Is there an ideal approach for rapid-sequence induction in hypertensive patients?

Journal of Clinical Anesthesia
Zekeriyya AlanoğluFiliz Tüzüner

Abstract

To compare 4 different anesthesia induction protocols, in a simulated model of rapid-sequence induction, in controlled hypertensive patients. Prospective, randomized, double-blind, clinical investigation. Large metropolitan university hospital. 120 ASA II-III adult hypertensive patients. Patients were allocated to 4 groups at random. After preoxygenation for 3 minutes, induction and tracheal intubation was performed in a 30 degrees head-up position. Thiopental (5-7 mg/kg) was the induction agent. Study groups were as follows: group LS (n = 30), lidocaine (1.5 mg/kg) and succinylcholine (1 mg/kg); group LR (n = 30), lidocaine (1.5 mg/kg) and rocuronium (1 mg/kg); group RS (n = 30), remifentanil (1 microg/kg) and succinylcholine (1 mg/kg); group RR (n = 30), remifentanil (1 microg/kg) and rocuronium (1 mg/kg). Patients were intubated 60 seconds after administration of muscle relaxant. Hemodynamic data were obtained before induction (baseline), after induction, at intubation, and at 1, 3, 5, and 10 minutes after intubation. More than 20% change in blood pressure and heart rate was considered significant. Systolic and mean arterial blood pressures at intubation and 1 and 3 minutes after intubation were higher in group LS compared w...Continue Reading

References

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Citations

Apr 5, 2014·Journal of the American Veterinary Medical Association·Carolina H Riccó, Natalia Henao-Guerrero
Jun 27, 2015·Clinical and Experimental Hypertension : CHE·Sachi OhnoKazuna Sugiyama
Aug 13, 2010·Acta Anaesthesiologica Scandinavica·A G JensenUNKNOWN Clinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine
Sep 29, 2015·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Sandra A LoweJoanne M Said
Oct 30, 2015·The Cochrane Database of Systematic Reviews·Diem T T TranJeffrey J Perry
Apr 24, 2008·Anesthesiology·Alison J Macarthur
Jul 19, 2008·Anesthesia and Analgesia·Lars Peter Wang, Michael James Paech

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