Is there an increased familial prevalence of psychopathology in children with nonverbal learning disorders?

Journal of Learning Disabilities
K M Antshel, Fahad M Khan

Abstract

The cognitive and behavioral symptoms of nonverbal learning disabilities (NLD) have been described by previous investigators. Nevertheless, we know far less about the potential genetic contributions that may predispose a child to have NLD. An endophenotype model was investigated in 5 samples of children ages 9 to 15 years: NLD (n = 32); reading disorders (RD; n = 59); participants with a psychiatric diagnosis but without a learning disability (n = 55); typically developing controls (n = 31); and children with velocardiofacial syndrome (VCFS), a chromosomal deletion syndrome that has been proposed as being an exemplar of NLD (VCFS + NLD; n = 20). Based on a family genetic interview, the authors' data suggest that children with NLD, RD, or a psychiatric diagnosis have a higher prevalence rate of attention-deficit/hyperactivity disorder (ADHD) and substance abuse/dependence. Psychiatric controls and children with NLD--but not children with RD-- showed higher prevalence rates of familial bipolar disorder.

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Citations

Apr 5, 2011·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Otfried Spreen
Mar 6, 2012·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Jodene Goldenring FineKayla A Musielak
Feb 26, 2015·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Margaret Semrud-ClikemanJesse Bledsoe
Dec 2, 2008·Pediatric Clinics of North America·Lieven Lagae
May 28, 2013·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Irene C Mammarella, Cesare Cornoldi
Dec 4, 2009·Journal of Child Neurology·Roger A Brumback
May 11, 2012·Journal of Learning Disabilities·Kelly SchochVandana Shashi
Apr 24, 2021·Journal of the American Academy of Child and Adolescent Psychiatry·Prudence W FisherHillary D Litwin

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