Is there an "unhealthy volunteer effect" in mental health outpatient research?

Psychiatry Research
Paul N PfeifferKara Zivin

Abstract

The ability to generalize clinical research findings depends on whether patients who agree to participate in studies have more or less severe illness than applicable clinical populations. We analyzed data from standardized clinical interviews given to patients seeking outpatient mental health treatment to determine whether there were differences between those who were willing to consider research participation and those who were not. Univariate and multivariable logistic regression analyses were conducted using measures of demographics, symptom and illness severity, and social environment. Factors associated with increased likelihood of willingness to consider research participation in the multivariable analysis were: moderate to severe depressive symptoms (OR=1.26; 95%CI: 1.07,1.48), hazardous drinking (OR=1.44, 95%CI: 1.19,1.75), having 1-15 days of partial disability due to mental illness (OR=1.19, 95%CI: 1.00,1.42), having any mental health outpatient visits in the last 2 years (OR=1.24; 95%CI: 1.09,1.42), and having a family member with mental illness (OR=1.57, 95%CI: 1.37,1.79). These results suggest an "unhealthy volunteer effect"-that patients interested in volunteering for outpatient mental health research have more se...Continue Reading

References

Aug 11, 1992·Archives of General Psychiatry·J B WilliamsB Rounsaville
Jan 1, 1997·General Hospital Psychiatry·M R ThomasS L Dubovsky
Dec 6, 2000·Journal of Clinical Psychopharmacology·A HoferW W Fleischhacker
Feb 24, 2001·Journal of Health & Social Policy·J M TrauthE Ricci
Feb 24, 2001·The Journal of Nervous and Mental Disease·E H FischerJ W Goethe
Apr 16, 2002·Journal of Consulting and Clinical Psychology·Peter A VanableStephen A Maisto
Jul 16, 2003·Psychiatry Research·George E JaskiwMilton E Strauss
Jul 1, 1957·Journal of Neurosurgery·F H MAYFIELD
Apr 15, 2004·Social Science & Medicine·R F BrownM H N Tattersall
Apr 12, 2005·Journal of Psychosomatic Research·Bernd LöweKerstin Gräfe
Mar 18, 2008·Journal of the American Board of Family Medicine : JABFM·Arch G MainousMark Carnemolla
Mar 3, 2009·American Journal of Epidemiology·John F McCarthyFrederic C Blow

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Citations

May 30, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Paige L WilliamsUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group P1055 Study Team
Apr 16, 2013·Psychiatry and Clinical Neurosciences·Toshihiko NagataChiho Yoshimura
Aug 14, 2012·Psychiatry Research·Anouk L GrubaughBartley Christopher Frueh

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