PMID: 11331624May 2, 2001Paper

Is there any physiological role for gonadotrophin oligosaccharide heterogeneity in humans? II. A biochemical point of view

Human Reproduction
J A Dias

Abstract

Heterogeneity of gonadotrophin oligosaccharides caused either by pharmacological intervention or which occurs naturally during normal physiological changes is well documented. Recent advances in structure determination of oligosaccharides has to some extent led to a better appreciation of how oligosaccharide heterogeneity may affect protein folding, stability, measurement and modulation of receptor binding. Here it is discussed how carbohydrate structure can impact upon gonadotrophin structure and function. It is well documented that oligosaccharides can serve as a cognate site for protein binding. One functional aspect of gonadotrophin glycosylation heterogeneity is the modulation of receptor binding affinity, yielding partially agonistic glycoforms. Carbohydrate heterogeneity is problematic for a clinical chemist if immunochemical assays are sensitive to heterogeneity. However, even measurements made without such interference may not accurately reflect the biological activity that is a collective result of all isoforms in the circulation, and perhaps of the genotype of each individual. Moreover, oligosaccharide heterogeneity may affect heterodimer stability, therefore, biological activity and immunochemical activity, not to m...Continue Reading

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Citations

Jun 28, 2011·Reviews in Endocrine & Metabolic Disorders·Brian J Arey, Francisco J López
Jul 24, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Linda M ThienpontAndré P De Leenheer
Apr 17, 2007·Animal Reproduction Science·G Perera-MarínE González-Padilla
Jun 2, 2006·Reproduction, Fertility, and Development·E ArrietaG Perera-Marín

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